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Hexestrol

Name: Hexestrol
Brand: TargetMol
SKU: T6533
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6533Cas No. 84-16-2

Alias meso-Hexestrol, Hexestrofen, Hexanoestrol

Hexestrol (Hexanoestrol) binds to ERα and ERβ with EC50 of 0.07 nM and 0.175 nM, respectively.

Hexestrol

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Purity: 99.2%

Catalog No. T6533Alias meso-Hexestrol, Hexestrofen, HexanoestrolCas No. 84-16-2

Hexestrol (Hexanoestrol) binds to ERα and ERβ with EC50 of 0.07 nM and 0.175 nM, respectively.

Pack Size	Price	Availability
100 mg	$47	In Stock
200 mg	$68	In Stock
500 mg	$112	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock

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Batch Information

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Purity:99.2%

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	Hexestrol (Hexanoestrol) binds to ERα and ERβ with EC50 of 0.07 nM and 0.175 nM, respectively.
Targets&IC50	ERβ:0.175 nM(EC50), ERα:0.07 nM(EC50)
In vitro	Hexestrol binds to ERα with EC50 of 0.07 nM and to ERβ with EC50 of 0.175 nM. [1] Hexestrol inhibits activity of AKR1B13 with IC50 of 3.2 μM. [2] Hexestrol inhibits the d-galactose dehydrogenase activity of thermophilus aldose 1-dehydrogenase with IC50 of 0.063 mM. [3] Hexestrol inhibits the dehydrogenase activity of AKR1C20 towards 10 μM 4-androsten-3α-o1-17-one with IC50 values of 2.7 μM. [4] Hexestrol inhibits 17HSD5 with IC50 of 30 μM, and inhibits TBER1 with IC50 of 0.8 μM. [5] Hexestrol reacts with DNA through the catechol quinone, thus can be a carcinogen. [6]
In vivo	Hexestrol administered intraperitoneally at dose of 6 mg/kg may decrease ovulation in mice, as evident by smaller ovaries and decreased luteal bodies and oocytes. [7]
Synonyms	meso-Hexestrol, Hexestrofen, Hexanoestrol

Chemical Properties

Molecular Weight	270.37
Formula	C₁₈H₂₂O₂
Cas No.	84-16-2
Smiles	[C@H]([C@H](CC)C1=CC=C(O)C=C1)(CC)C2=CC=C(O)C=C2
Relative Density.	1.093 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 50 mg/mL (184.93 mM), Sonication is recommended.

Ethanol: 39 mg/mL (144.25 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6986 mL	18.4932 mL	36.9864 mL	184.9318 mL
5 mM	0.7397 mL	3.6986 mL	7.3973 mL	36.9864 mL
10 mM	0.3699 mL	1.8493 mL	3.6986 mL	18.4932 mL
20 mM	0.1849 mL	0.9247 mL	1.8493 mL	9.2466 mL
50 mM	0.0740 mL	0.3699 mL	0.7397 mL	3.6986 mL
100 mM	0.0370 mL	0.1849 mL	0.3699 mL	1.8493 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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