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RS-25344

Name: RS-25344
Brand: TargetMol
SKU: T9239
Price: 80 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9239Cas No. 152814-89-6

RS-25344 is a potent and selective phosphodiesterase (PDE) 4 inhibitor. It inhibits eosinophil chemotaxis and increases progressive motility of spermatozoa in vitro.

RS-25344

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Purity: 98.98%

Catalog No. T9239Cas No. 152814-89-6

RS-25344 is a potent and selective phosphodiesterase (PDE) 4 inhibitor. It inhibits eosinophil chemotaxis and increases progressive motility of spermatozoa in vitro.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$80	In Stock	In Stock
5 mg	$181	In Stock	In Stock
10 mg	$272	In Stock	In Stock
25 mg	$448	In Stock	In Stock
50 mg	$630	In Stock	In Stock
100 mg	$852	In Stock	In Stock
200 mg	$1,130	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$197	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.98%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

RS-25344 AI Summary

RS-25344 inhibits full-length PDE4A4 with an IC50 of 22.0 nM and induces SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 with an EC50 of 17.0 nM. Additionally, this compound demonstrates bioactivity as an inhibitor of the recombinant human PDE4D7 catalytic domain, exhibiting an IC50 value of 19.0 nM in assays utilizing cAMP as a substrate..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	RS-25344 is a potent and selective phosphodiesterase (PDE) 4 inhibitor. It inhibits eosinophil chemotaxis and increases progressive motility of spermatozoa in vitro.
Targets&IC50	PDE4:0.28 nM, PDE1:100 nM, PDE2:160 nM, PDE3:330 nM

Chemical Properties

Molecular Weight	375.34
Formula	C₁₉H₁₃N₅O₄
Cas No.	152814-89-6
Smiles	O=C1N(C=2C(C(=O)N1CC=3C=CN=CC3)=CC=CN2)C4=CC(N(=O)=O)=CC=C4
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (133.21 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6643 mL	13.3213 mL	26.6425 mL	133.2126 mL
5 mM	0.5329 mL	2.6643 mL	5.3285 mL	26.6425 mL
10 mM	0.2664 mL	1.3321 mL	2.6643 mL	13.3213 mL
20 mM	0.1332 mL	0.6661 mL	1.3321 mL	6.6606 mL
50 mM	0.0533 mL	0.2664 mL	0.5329 mL	2.6643 mL
100 mM	0.0266 mL	0.1332 mL	0.2664 mL	1.3321 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc