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Integrin

Integrins are proteins that function mechanically, by attaching the cell cytoskeleton to the extracellular matrix (ECM), and biochemically, by sensing whether adhesion has occurred. The integrin family of proteins consists of alpha and beta subtypes, which form transmembrane heterodimers.

  • Tirofiban hydrochloride monohydrate
    T2537150915-40-5
    Tirofiban hydrochloride monohydrate (MK-383 Hydrochloride) is a potent non-peptide, glycoprotein IIb/IIIa (integrins alphaIIbbetaIII) antagonist.
    • $40
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  • Cyclo(-RGDfK)
    T6812161552-03-0
    Cyclo(-RGDfK) (Cyclo (-RGDfK)) is an effective and specific αvβ3 integrin inhibitor.
    • $55
    In Stock
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  • RO0270608
    T36716220846-33-3In house
    RO0270608, the active metabolite of R411, is an orally active dual α4β1/α4β7 integrin antagonist with anti-inflammatory activity that modulates inflammation and can be used in the study of allergic inflammatory responses.
    • $117
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  • P8RI acetate
    T39615L
    P8RI acetate is a biomimetic peptide of CD31 and an agonist of CDP8RI acetate shows an immunosuppressive effect through the restoration of the CD31 inhibitory pathway.
    • $56
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  • α2β1 Integrin Ligand Peptide acetate
    TP1484L
    α2β1 Integrin Ligand Peptide acetate (α2β1 Integrin Ligand Peptide acetate (134580-64-6)) is a potential antagonist of α2β1 integrin receptor. α2β1 Integrin Ligand Peptide interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellular signals into cells.
    • $97
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  • Arg-Gly-Asp TFA (99896-85-2(free base))
    T4613
    Arg-Gly-Asp TFA (99896-85-2(free base)) (RGD Trifluoroacetate) is a tripeptide that effectively triggers cell adhesion, addresses certain cell lines and elicits specific cell responses; binds to integrins.
    • $58
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    TargetMol | Citations Cited
  • Gly-Arg-Gly-Asp-Ser acetate(96426-21-0 free base)
    TP1459L
    Gly-Arg-Gly-Asp-Ser (GRGDS) acetate is a cell binding protein domain derived from the cell-binding region of fibronectin.
    • $42
    In Stock
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  • P11 acetate
    TP1879L1
    P11 acetate is an integrin αvβ3-vitronectin interaction antagonist(IC50 = 2.74 nM).
    • $82
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  • K34c hydrochloride
    T41151L In house
    K34c hydrochloride is an alpha5β1 integrin antagonist for glioblastoma study.
    • $350
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  • Orbofiban TFA
    T61345L In house
    Orbofiban TFA is an orally active GPIIb/IIIa platelet receptor antagonist with inhibitory effects on platelet aggregation for the study of unstable coronary syndromes.
    • $297
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  • LXW7
    TP14741313004-77-1
    LXW7 is an octamer disulfide cyclic peptide and αvβ3 integrin ligand, acts as a potent and specific endothelial progenitor cells (EPCs) and endothelial cells (ECs) targeting ligand. LXW7 is a disulfide cyclic octa-peptide (cGRGDdvc) containing unnatural amino acids flanking both sides of the main functional motif.
    • $133
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  • GRGDSP acetate(91037-75-1 free base)
    TP1290
    GRGDSP acetate(91037-75-1 free base) is a synthetic linear RGD peptide and is an integrin inhibitor.
    • $78
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  • Elarofiban
    T27250198958-88-2In house
    Elarofiban(RWJ-53308) is a novel and orally active GPIIb/IIIa antagonist.
    • $397
    In Stock
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  • αvβ1 integrin-IN-1
    T134731689540-62-2In house
    αvβ1 integrin-IN-1 is a potent and selective inhibitor of αvβ1 integrin (IC50 of 0.63 nM) with antifibrotic effects.
    • $129
    In Stock
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  • Roxifiban acetate
    T24733176022-59-6In house
    Roxifiban acetate(DMP 754 acetate) is a potent GP IIb / IIIa antagonist that exhibits antiplatelet aggregation activity via immune mediation and can be used in the study of human thrombocytopenia.
    • $518
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  • Elarofiban TFA
    T27250L198958-89-3In house
    Elarofiban TFA (RWJ-53308 TFA) is a novel and orally active and selective GPIIb/IIIa antagonist for the study of cardiovascular disease.
    • $195
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  • Arg-Gly-Asp-Ser acetate
    T10366L
    Arg-Gly-Asp-Ser acetate is an integrin binding sequence that directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1. Arg-Gly-Asp-Ser acetate inhibits integrin receptor function.
    • $35
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  • Hexapeptide-10 Acetate
    TP2384L
    Hexapeptide-10 Acetate (Hexapeptide-10 Acetate) is a synthetic peptide. It increases the synthesis of laminin V and α6-integrin to promote cell binding, with extraordinary visible skin restructuring and firming abilities.
    • $50
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  • ICAM-1-IN-1
    T13147251994-14-6In house
    ICAM-1-IN-1 is a potent and selective E-selectin(IC50 = 7 nM) and ICAM-1(IC50 = 5 nM) inhibitor.
    • $195
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  • Firategrast
    TQ0291402567-16-2In house
    Firategrast (SB 683699) is an orally active and specific α4β1/α4β7 integrin antagonist.Firategrast reduces the transport of lymphocytes into the central nervous system (CNS) and decreases multiple sclerosis (MS) activity.Firategrast is used in relapsing-remitting multiple sclerosis.Firategrast treatment is associated with a median cerebrospinal fluid associated with modest reductions in CD4, CD8, and CD19 lymphocyte counts.
    • $51
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  • SB273005
    T6657205678-31-5In house
    SB273005 is an orally active and potent nonpeptide integrin αvβ3 antagonist that inhibits αvβ3 and αvβ5 and reduces the production of Th2 cells and the cytokine IL-10 in pregnant mice.
    • $152
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  • Cucurbitacin B
    T34046199-67-3
    Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation through up-regulation of PTEN. Cucurbitacin B is an effective inhibitor of HIF-1 and provide new perspectives into the mechanism of its anticancer activity. Cucurbitacin B inhibits proliferation and induces apoptosis via STAT3 pathway inhibition in A549 lung Y cells.
    • $44
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    TargetMol | Citations Cited
  • Cyclo(RGDyK)
    T8726217099-14-4
    Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.
    • $1,520
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  • A-205804
    T2254251992-66-2
    A-205804 is a specific and effective inhibitor of E-selectin( IC50=20 nM ) and ICAM-1(IC50=25 nM) expression.
    • $37
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    TargetMol | Citations Cited
  • Bestatin hydrochloride
    T352965391-42-6
    Bestatin hydrochloride (Ubenimex hydrochloride) is an inhibitor of aminopeptidase N (APN)/CD13 and aminopeptidase B.
    • $47
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    TargetMol | Citations Cited
  • Cilengitide
    T2494188968-51-6
    Cilengitide (EMD 121974) is a potent integrin inhibitor for the αvβ3/5 receptor (IC50: 4.1/79 nM, in cell-free assays); ~10-fold selectivity against gpIIbIIIa.
    • $45
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    TargetMol | Citations Cited
  • αvβ1 integrin-IN-2
    T797922234874-68-9
    αvβ1 integrin-IN-2 (compound 32) is a potent inhibitor of ανβ1 and α5β1 integrins, exhibiting IC50 values of 0.9 nM and 33 nM, respectively. Additionally, this compound inhibits a range of other integrins, with IC50 values of 380 nM (ανβ3), 280 nM (ανβ5), 230 nM (ανβ6), and 87 nM (ανβ8) as determined by the SPRA assay [1].
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  • Efalizumab
    T76924214745-43-4
    Efalizumab, a novel potent regulator of T cells, is a humanized LFA-1 α subunit (CD11a) monoclonal antibody. Efalizumab has inhibitory effects on T cell activation, skin T cell transport, and T cell adhesion to keratinocytes, and can be used to study plaque psoriasis and psoriatic arthritis.
    • $255
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  • Bersanlimab
    T769271987854-08-9
    Bersanlimab (BI-505) is a fully human monoclonal antibody targeting Intercellular Adhesion Molecule-1 (ICAM-1).Bersanlimab has anticancer properties and can be used to study relapsed/refractory multiple myeloma.
    • $347
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  • Obtustatin triacetate
    T78219
    Obtustatin triacetate, a 41-residue non-RGD disintegrin isolated from the venom of Vipera lebetina obtusa, serves as a potent and selective inhibitor of the integrin α1β1's adhesion to type IV collagen. This compound holds significance in cancer research due to its ability to inhibit angiogenesis [1].
    • Inquiry Price
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  • FITC-Ahx-Gly-Arg-Gly-Asp-Ser-Pro
    T801272022956-44-9
    FITC-Ahx-Gly-Arg-Gly-Asp-Ser-Pro, also known as FITC-linked GRGDSP, is a fluorescent peptide with integrin inhibitory properties. This compound impedes tumor cell adherence to endothelial blood vessel cells, potentially restricting metastasis [1].
    • Inquiry Price
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  • αvβ6 integrin inhibitor 2
    T79140313709-47-6
    αvβ6 Integrin Inhibitor 2 is a potent inhibitor of αvβ6 integrin, demonstrating an inhibition concentration (IC50) of 96.5 nM.
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  • mP6
    T817542700321-79-3
    mP6 (Myr-FEEERA-OH), a myristoylated peptide, selectively inhibits Gα 13's interaction with integrin β 3 while preserving talin-dependent integrin function. Additionally, mP6 impedes the GTPase activity of Rac1, Rap1, and Rab7, effectively reducing the infection of CHO-A24 cells [1].
    • Inquiry Price
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  • Bimosiamose
    T14574187269-40-5
    Bimosiamose has anti-inflammatory effects[1]. Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, L-selectin, and P-selectin respectively.
    • $213
    35 days
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  • αvβ1 integrin-IN-1 TFA (1689540-62-2 free base)
    T13473L
    αvβ1 integrin-IN-1 TFA is an effective and selective αvβ1 integrin inhibitor (IC50: 0.63 nM).
    • $1,110
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  • cRGDfK-thioacetyl ester
    T80214393781-65-2
    cRGDfK-thioacetyl ester, a bioactive polypeptide, exhibits selective affinity for integrins and can modify near-infrared (NIR) fluorescent probes for targeted cancer imaging [1] [2].
    • Inquiry Price
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  • Anti-Mouse IL-1a Antibody (ALF-161)
    T80586
    Anti-Mouse IL-1a Antibody is an IgG1 subtype inhibitor specific to mouse IL-1a, derived from the Armenian Hamster.
    • $198
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  • VnP-16
    T80529
    VnP-16 enhances bone formation by stimulating the differentiation and activity of osteoblasts via direct β1 integrin engagement, which subsequently activates FAK [1].
    • Inquiry Price
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  • BIRT-377
    T23796213211-10-0
    BIRT-377 is a negative allosteric and orally bioavailable inhibitor of ICAM-1 and LFA-1(Ki = 25.8 nM). BIRT-377 inhibits the production of IL-2 and can be used in studies about inflammatory and immune disorders.
    • $50
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  • BI-1950
    T145581159724-42-1
    BI-1950 is a highly potent lymphocyte function associated antigen-1 (LFA-1) inhibitor and the LFA-1 is an essential component in normal immune system function and a target for drug discovery[1].
    • $1,820
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  • Carotegrast methyl
    T30751401905-67-7
    Carotegrast methyl (AJM300), an orally-active small molecule, can antagonize the α4 integrin receptor. It is a specific and dual α4β1/α4β7 integrin antagonist.
    • $77
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  • Balamapimod
    T16100863029-99-6
    Balamapimod is a reversible inhibitor of Ras/Raf/MEK. It also has a potential anti-tumor activity.
    • $1,520
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  • Fibronectin
    T4096086088-83-7
    Fibronectin is a macromolecular glycoprotein found in blood, connective tissue, and cell surfaces that serves as a biomarker for tissue damage.Fibronectin is recognized by the integrin family of surface receptors.Fibronectin is used in the study of primary open-angle glaucoma.Fibronectin is used in the study of primary open-angle glaucoma.Fibronectin is used in the study of metastatic prostat
    • $228
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  • Bexotegrast
    T399332376257-44-0
    Bexotegrast (PLN-74809) is an orally active and potent inhibitor of αvβ6 and αvβ1 integrins with antifibrotic effects, inhibits αvβ6 and αvβ1-induced activation of TGF-β, and can be used for the study of idiopathic pulmonary fibrosis (IPF) and non-specific interstitial pneumonia (NSIP).
    • $125
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  • Cyclo(RGDyK) trifluoroacetate
    T6813250612-42-1
    Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.
    • $38
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  • E7820
    T4435289483-69-8
    E7820 (ER68203-00) is an angiogenesis inhibitor by suppressing integrin a2 (a cell adhesion molecule expressed on endothelial cells).
    • $30
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  • BIO-1211
    T21868187735-94-0
    BIO-1211 is a more potent inhibitor of α4β1 (VLA-4, IC50 = 4 nM) over α4β7(IC50 = 2 μM).
    • $113
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  • PLN-1474
    T601012408065-32-5
    PLN-1474 is a potent αVβ1 inhibitor with IC50 < 50 nM.
    • $58
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  • A-286982
    T21781280749-17-9
    A 286982 is an inhibitor that blocks the integrin-ligand interaction between leukocyte function-associated antigen-1 (LFA-1) and intercellular adhesion molecule-1.
    • $30
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  • Cyclo(Ala-Arg-Gly-Asp-Mamb)
    T80075153381-95-4
    Cyclo(Ala-Arg-Gly-Asp-Mamb) is a selective antagonist of the RGD peptide with potential applications in pulmonary arterial hypertension research [1].
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