Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Compound 106 (compound 10ic) induces apoptosis in B16-F10 melanoma cells and potently inhibits metastatic nodules in mouse models of lung metastatic melanoma, suggesting its utility in the study of cancer, particularly lung metastatic melanoma [1].
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Description | Compound 106 (compound 10ic) induces apoptosis in B16-F10 melanoma cells and potently inhibits metastatic nodules in mouse models of lung metastatic melanoma, suggesting its utility in the study of cancer, particularly lung metastatic melanoma [1]. |
In vitro | Anticancer agent 106 (Compound 106; 0.28-55 μM; 24 h) diminishes the viability of B16-F10 melanoma cells in a dose-dependent manner, with an IC50 of 4.8 μM [1]. At concentrations ranging from 5-20 μM over 48 hours, the same agent induces apoptosis in B16-F10 melanoma cells [1]. |
In vivo | Anticancer agent 106 (9-9.5 mg/kg; i.p.; every 3rd day for 22 days) inhibits metastatic nodules in a murine model of pulmonary metastatic melanoma [1]. |
Molecular Weight | 475.56 |
Formula | C26H25N3O4S |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Anticancer agent 106 Apoptosis inhibitor inhibit