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CyPep-1 is a novel cationic lytic peptide with antitumor activity. It exerts potent cytotoxicity by interacting with the negatively charged membranes of cancer cells. CyPep-1 demonstrates strong cell lytic activity against cancer cells both in vitro and in vivo, making it useful for researching solid tumors.

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| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
| Description | CyPep-1 is a novel cationic lytic peptide with antitumor activity. It exerts potent cytotoxicity by interacting with the negatively charged membranes of cancer cells. CyPep-1 demonstrates strong cell lytic activity against cancer cells both in vitro and in vivo, making it useful for researching solid tumors. |
| In vitro | CyPep-1 (0-40 μg/mL; 15-360 minutes) exhibits dose- and time-dependent cytotoxic effects on tumor cell lines, while affecting normal cell lines to a lesser extent. |
| In vivo | CyPep-1 (intratumoral injection; 1200 µg; single dose) demonstrates antitumor effects in a mouse model of breast cancer. |
| Molecular Weight | 3451.09 |
| Formula | C152H265N57O35 |
| Cas No. | 1319804-91-5 |
| Smiles | [C@@H](CC1=CC=C(O)C=C1)(NC([C@@H](NC([C@@H](NC([C@H](CC2=CC=C(O)C=C2)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@H](CC3=CC=C(O)C=C3)N)=O)=O)CCCNC(=N)N)=O)CCCCN)=O)CCCCN)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCC(N)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)=O)CCCCN)=O)[C@@H](C)O)=O)CC(C)C)=O)CCCNC(=N)N)=O)[C@@H](C)C)=O)C)=O)CCCCN)=O)C)=O)[C@H](CC)C)=O)=O)CCCCN)=O)CCCNC(=N)N)=O)C(N[C@H](C(N[C@@H](CCC(O)=O)C(O)=O)=O)[C@H](CC)C)=O |
| Sequence | Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Lys-Thr-Leu-Arg-Val-Ala-Lys-Ala-Ile-Tyr-Lys-Arg-Tyr-Ile-Glu |
| Sequence Short | YGRKKRRQRRRGKTLRVAKAIYKRYIE |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Dissolve 2 mg of the compound in 100 μL DMSO
to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO
stock solution to 400 μL PEG300
and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O
and mix thoroughly until a homogeneous solution is obtained.
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