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MC-Val-Ala-PAB-PNP

Name: MC-Val-Ala-PAB-PNP
Brand: TargetMol
SKU: T18318
Price: 59 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T18318Cas No. 1639939-40-4

MC-Val-Ala-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

MC-Val-Ala-PAB-PNP

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Purity: 96.71%

Catalog No. T18318Cas No. 1639939-40-4

MC-Val-Ala-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Pack Size	Price	Availability
5 mg	$59	In Stock
10 mg	$81	In Stock
25 mg	$125	In Stock
50 mg	$178	In Stock
100 mg	$262	In Stock
1 mL x 10 mM (in DMSO)	$87	In Stock

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Batch Information

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Purity:96.71%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	MC-Val-Ala-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
In vitro	ADCs consist of an antibody attached to an ADC cytotoxin through an ADC linker.

Chemical Properties

Molecular Weight	651.66
Formula	C₃₂H₃₇N₅O₁₀
Cas No.	1639939-40-4
Smiles	O(C(OCC1=CC=C(NC([C@@H](NC([C@@H](NC(CCCCCN2C(=O)C=CC2=O)=O)[C@H](C)C)=O)C)=O)C=C1)=O)C3=CC=C(N(=O)=O)C=C3
Relative Density.	1.323 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (76.73 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5345 mL	7.6727 mL	15.3454 mL	76.7271 mL
5 mM	0.3069 mL	1.5345 mL	3.0691 mL	15.3454 mL
10 mM	0.1535 mL	0.7673 mL	1.5345 mL	7.6727 mL
20 mM	0.0767 mL	0.3836 mL	0.7673 mL	3.8364 mL
50 mM	0.0307 mL	0.1535 mL	0.3069 mL	1.5345 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc