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Taurolithocholic Acid 3-sulfate sodium salt (Synonyms: Taurolithocholic acid 3-sulfate disodium, 3-Sulfotauroli...)
Catalog No. T37771 Copy Product Info
Purity: 99.40%
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Taurolithocholic Acid 3-sulfate sodium salt is a GPR39 agonist. In the absence of Zn²⁺, its EC50 values are 71.6 μM and 69.4 μM in M39-20 and hGPR39-2 cells, respectively; in the presence of Zn²⁺, the values are 9 μM and 9.6 μM, respectively. Taurolithocholic Acid 3-sulfate sodium salt activates the GPR39 receptor and mediates intracellular calcium signaling pathways independently of the Zn²⁺-binding sites H17 and H19, and can be used in research on gallbladder-related diseases.
Taurolithocholic Acid 3-sulfate sodium salt
Copy Product Info🥰Excellent
Catalog No. T37771
Synonyms Taurolithocholic acid 3-sulfate disodium, 3-Sulfotaurolithocholic acid disodium
Taurolithocholic Acid 3-sulfate sodium salt is a GPR39 agonist. In the absence of Zn²⁺, its EC50 values are 71.6 μM and 69.4 μM in M39-20 and hGPR39-2 cells, respectively; in the presence of Zn²⁺, the values are 9 μM and 9.6 μM, respectively. Taurolithocholic Acid 3-sulfate sodium salt activates the GPR39 receptor and mediates intracellular calcium signaling pathways independently of the Zn²⁺-binding sites H17 and H19, and can be used in research on gallbladder-related diseases.
Cas No. 64936-83-0
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $63 | - | In Stock | |
| 5 mg | $158 | - | In Stock | |
| 10 mg | $237 | - | In Stock | |
| 25 mg | $392 | - | In Stock | |
| 50 mg | $585 | - | In Stock | |
| 100 mg | $833 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.40%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Taurolithocholic Acid 3-sulfate sodium salt is a GPR39 agonist. In the absence of Zn²⁺, its EC50 values are 71.6 μM and 69.4 μM in M39-20 and hGPR39-2 cells, respectively; in the presence of Zn²⁺, the values are 9 μM and 9.6 μM, respectively. Taurolithocholic Acid 3-sulfate sodium salt activates the GPR39 receptor and mediates intracellular calcium signaling pathways independently of the Zn²⁺-binding sites H17 and H19, and can be used in research on gallbladder-related diseases. |
| Targets&IC50 | GPR39 without Zn2+ (human):69.4 μM (EC50), M39-20 cells (with Zn²⁺):9 μM (EC50), M39-20 cells (without Zn2+):71.6 μM (EC50), GPR39 with Zn2+ (human):9.6 μM (EC50) |
| In vitro | In the absence of Zn²⁺, the EC50 values of Taurolithocholic Acid 3-sulfate sodium salt on M39-20 and hGPR39-2 cells were 71.6 μM and 69.4 μM, respectively; in the presence of Zn²⁺, the EC50 values were 9 μM and 9.6 μM, respectively. |
| Synonyms | Taurolithocholic acid 3-sulfate disodium, 3-Sulfotaurolithocholic acid disodium |
| Molecular Weight | 607.73 |
| Formula | C26H43NNa2O8S2 |
| Cas No. | 64936-83-0 |
| Smiles | C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(NCCS(=O)([O-])=O)=O)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4([C@](C[C@@H](CC4)OS(=O)([O-])=O)([H])CC3)C.[Na+].[Na+] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | ||||||||||
| Solubility Information | Ethanol: 1 mg/mL (1.65 mM), Sonication is recommended. DMSO: 20 mg/mL (32.91 mM), Sonication is recommended. PBS (pH 7.2): 1 mg/mL (1.65 mM), Sonication is recommended. DMF: 25 mg/mL (41.14 mM), Sonication is recommended. | ||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween-80+45% Saline: 1 mg/mL (1.65 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||
Solution Preparation Table | |||||||||||
Ethanol/PBS (pH 7.2)/DMSO/DMF
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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