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Fmoc-N-PEG24-acid is a PEG-based linker for PROTACs, crucial for connecting two essential ligands to form PROTAC molecules. This linker facilitates selective protein degradation by utilizing the ubiquitin-proteasome system within cells.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $46 | 5 days | |
10 mg | $65 | 5 days | |
25 mg | $105 | 5 days |
Description | Fmoc-N-PEG24-acid is a PEG-based linker for PROTACs, crucial for connecting two essential ligands to form PROTAC molecules. This linker facilitates selective protein degradation by utilizing the ubiquitin-proteasome system within cells. |
In vitro | PROTACs comprise two distinct ligands linked together: one ligand binds to an E3 ubiquitin ligase, and the other binds to the target protein. They harness the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1]. |
Molecular Weight | 1368.59 |
Formula | C66H113NO28 |
Cas No. | 2170484-59-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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