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LY2794193

Name: LY2794193
Brand: TargetMol
SKU: T15807
Price: 1399 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15807Cas No. 2173037-97-1

Alias LY 2794193

LY2794193, a potent and selective mGlu3 (metabotropic glutamate 3) receptor agonist, Ki=0.927 nM, EC50=0.47 nM, reduces akathisia seizures and depressive-like behaviors and increases GAT1, GLAST and GLT-1 protein levels in rats.

LY2794193

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Purity: 98.15%

Catalog No. T15807Alias LY 2794193Cas No. 2173037-97-1

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 mg	$1,399	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.15%

Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	LY2794193, a potent and selective mGlu3 (metabotropic glutamate 3) receptor agonist, Ki=0.927 nM, EC50=0.47 nM, reduces akathisia seizures and depressive-like behaviors and increases GAT1, GLAST and GLT-1 protein levels in rats.
Targets&IC50	mGluR3:0.47 nM (EC50), mGluR2:412 (ki), mGluR3:0.927 nM (ki), mGluR2:47.5 (EC50)
In vitro	When its agonist responses were examined in cells co-expressing a promiscuous G protein (Gαq), LY2794193 exhibited agonist activity against both hmGlu3 (EC50 value of 11.6 nM) and hmGlu2 (EC50 value of 277 nM).[1]
In vivo	Methods: Two doses of LY2794193 (0.1, 0.3, and 1 mg/kg, sc) and LY2794193 (1, 3, and 10 mg/kg, sc) were administered to rats; the first study employed dose levels, while the second evaluated higher doses; in each study, plasma and cerebrospinal fluid (CSF) levels were determined 1 h after LY2794193 administration. Results: Plasma and CSF levels of LY2794193 were observed at all dose levels, and a linear increase in each compartment with increasing dose was observed. The fraction of LY2794193 partitioning into the CSF was both low and highly consistent across dose levels, with a CSF to plasma ratio of 1% calculated over a 100-fold concentration range. [1]
Synonyms	LY 2794193

Chemical Properties

Molecular Weight	334.32
Formula	C₁₆H₁₈N₂O₆
Cas No.	2173037-97-1
Smiles	C(O)(=O)[C@H]1[C@]2([C@@]1([C@@](C(O)=O)(N)C[C@@H]2NC(=O)C3=CC(OC)=CC=C3)[H])[H]
Relative Density.	1.50 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 1 mg/mL (2.99 mM), when pH is adjusted to 14 with NaOH.

DMSO: 180 mg/mL (538.41 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9911 mL	14.9557 mL	29.9115 mL	149.5573 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.5982 mL	2.9911 mL	5.9823 mL	29.9115 mL
10 mM	0.2991 mL	1.4956 mL	2.9911 mL	14.9557 mL
20 mM	0.1496 mL	0.7478 mL	1.4956 mL	7.4779 mL
50 mM	0.0598 mL	0.2991 mL	0.5982 mL	2.9911 mL
100 mM	0.0299 mL	0.1496 mL	0.2991 mL	1.4956 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc