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Rifalazil
🥰Excellent
Catalog No. T16749Cas No. 129791-92-0
Alias KRM-1648, KRM1648, ABI-1648, ABI1648
Rifalazil (KRM-1648) is a benzophenazine antibiotic with antibacterial activity. It inhibits bacterial RNA polymerase, blocking the β-subunit, and is used in Chlamydia infection research.
Rifalazil
🥰Excellent
Catalog No. T16749Alias KRM-1648, KRM1648, ABI-1648, ABI1648Cas No. 129791-92-0
Rifalazil (KRM-1648) is a benzophenazine antibiotic with antibacterial activity. It inhibits bacterial RNA polymerase, blocking the β-subunit, and is used in Chlamydia infection research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $99 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Rifalazil (KRM-1648) is a benzophenazine antibiotic with antibacterial activity. It inhibits bacterial RNA polymerase, blocking the β-subunit, and is used in Chlamydia infection research. |
| In vitro | The MIC50 values of Rifalazil were 0.0015, 0.0039 and 0.0313 μg/ml for Clostridium difficile, Clostridium perfringens and Bacteroides fragile, respectively. Rifalazi showed antibacterial activity against gram-negative gut bacteria with MIC50 values of 16 μg/ml for Escherichia coli and 16 ug/ml for Klebsiella pneumoniae. [1] The MIC of Rifalazil against rifampicin-resistant mutants of Chlamydia pneumoniae was 0.125 μg/ml. [4] |
| In vivo | Treatment with Rifalazil (5 or 10 mg/kg orally for 15 weeks) improved the redness and swelling of the foot pads in mice with ulcer-infected models. [2] Rifalazil (20 mg/kg for 5 days) can treat and prevent recurrence of Clostridium difficile-associated diarrhea in hamsters. [3] |
| Synonyms | KRM-1648, KRM1648, ABI-1648, ABI1648 |
| Molecular Weight | 941.07 |
| Formula | C51H64N4O13 |
| Cas No. | 129791-92-0 |
| Smiles | C[C@H]1/C=C/C=C(C)\C(NC2=C3C(N=C4C(O3)=CC(N5CCN(CC(C)C)CC5)=CC4=O)=C6C(C2=O)=C(O)C(C)=C7C6=C(O)[C@](O/C=C/[C@H](OC)[C@@H](C)[C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@H]1O)(C)O7)=O |
| Relative Density. | 1.31g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||
| Solubility Information | DMSO: 4 mg/mL (4.25 mM), Sonication is recommended. | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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