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Rifalazil

Name: Rifalazil
Brand: TargetMol
SKU: T16749
Price: 99 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16749Cas No. 129791-92-0

Alias KRM-1648, KRM1648, ABI-1648, ABI1648

Rifalazil (KRM-1648) is a benzophenazine antibiotic with antibacterial activity. It inhibits bacterial RNA polymerase, blocking the β-subunit, and is used in Chlamydia infection research.

Rifalazil

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Catalog No. T16749Alias KRM-1648, KRM1648, ABI-1648, ABI1648Cas No. 129791-92-0

Rifalazil (KRM-1648) is a benzophenazine antibiotic with antibacterial activity. It inhibits bacterial RNA polymerase, blocking the β-subunit, and is used in Chlamydia infection research.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$99	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	Rifalazil (KRM-1648) is a benzophenazine antibiotic with antibacterial activity. It inhibits bacterial RNA polymerase, blocking the β-subunit, and is used in Chlamydia infection research.
In vitro	The MIC50 values of Rifalazil were 0.0015, 0.0039 and 0.0313 μg/ml for Clostridium difficile, Clostridium perfringens and Bacteroides fragile, respectively. Rifalazi showed antibacterial activity against gram-negative gut bacteria with MIC50 values of 16 μg/ml for Escherichia coli and 16 ug/ml for Klebsiella pneumoniae. [1] The MIC of Rifalazil against rifampicin-resistant mutants of Chlamydia pneumoniae was 0.125 μg/ml. [4]
In vivo	Treatment with Rifalazil (5 or 10 mg/kg orally for 15 weeks) improved the redness and swelling of the foot pads in mice with ulcer-infected models. [2] Rifalazil (20 mg/kg for 5 days) can treat and prevent recurrence of Clostridium difficile-associated diarrhea in hamsters. [3]
Synonyms	KRM-1648, KRM1648, ABI-1648, ABI1648

Chemical Properties

Molecular Weight	941.07
Formula	C₅₁H₆₄N₄O₁₃
Cas No.	129791-92-0
Smiles	C[C@H]1/C=C/C=C(C)\C(NC2=C3C(N=C4C(O3)=CC(N5CCN(CC(C)C)CC5)=CC4=O)=C6C(C2=O)=C(O)C(C)=C7C6=C(O)[C@](O/C=C/[C@H](OC)[C@@H](C)[C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@H]1O)(C)O7)=O
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 4 mg/mL (4.25 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (1.06 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0626 mL	5.3131 mL	10.6262 mL	53.1310 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc