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CG 428

Catalog No. T41224 CAS 2412055-93-5

CG 428 is a potent tropomyosin receptor Kinase (TRK) Degrader (uSMITETM) with a DC50 of 0.36 nM. CG 428 comprises an analog of the pan-TRK inhibitor GNF-8625 joined by a linker to the cereblon E3 ligase ligand pomalidomide. CG 428 shows selectivity for TRKA over TRKC and TRKB with Kds of 1nM, 4.2 nM, and 28 nM. CG 428 inhibits the growth of KM12 colon cancer cells with an IC50 of 2.9 nM.

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CG 428, CAS 2412055-93-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 178.00
5 mg	In stock	$ 445.00
10 mg	In stock	$ 656.00
25 mg	In stock	$ 987.00
50 mg	In stock	$ 1,380.00
100 mg	In stock	$ 1,880.00
500 mg	In stock	$ 3,780.00
1 mL * 10 mM (in DMSO)	In stock	$ 460.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Molecular Weight	814.86
Formula	C43H43FN10O6
CAS No.	2412055-93-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90.0 mg/mL (110.4 mM)

References and Literature

1. Chen L, et al. Discovery of First-In-Class Potent and Selective Tropomyosin Receptor Kinase Degraders. J Med Chem. 2020;63(23):14562-14575.

Related compound libraries

This product is contained In the following compound libraries：

Tyrosine Kinase Inhibitor Library Inhibitor Library Kinase Inhibitor Library Anti-Cancer Active Compound Library Bioactive Compounds Library Max Anti-Cancer Compound Library Bioactive Compound Library

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Keywords

CG 428 2412055-93-5 Tyrosine Kinase/Adaptors Trk receptor CG428 CG-428 inhibitor inhibit

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