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Taurochenodeoxycholic Acid

Taurochenodeoxycholic Acid
Taurochenodeoxycholic Acid (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid.
Catalog No. T2A2481Cas No. 516-35-8
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Purity:99.86%
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Taurochenodeoxycholic Acid

Catalog No. T2A2481Cas No. 516-35-8

Taurochenodeoxycholic Acid (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
25 mg$39In Stock
50 mg$59In Stock
100 mg$89In Stock
200 mg$128In Stock
500 mg$219In Stock
1 mL x 10 mM (in DMSO)$34In Stock
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Product Introduction

Bioactivity
Description
Taurochenodeoxycholic Acid (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid.
In vitro
Studies have suggested that taurochenodeoxycholic acid as a signaling molecule shows obvious anti-inflammatory and immune regulation properties. Taurochenodeoxycholic acid dramatically improves the apoptosis rate of NR8383 cells in a concentration-dependent manner. In the meantime, PKC mRNA levels and activities are significantly augmented by taurochenodeoxycholic acid treatments. In addition, JNK, caspase-3 and caspase-8 mRNA expression levels and activities are increased by taurochenodeoxycholic acid.
In vivo
Taurochenodeoxycholic acid significantly normalizes the clinical inflammatory parameters, prevented indomethacin-induced increases in the biliary contents of secondary bile acids and hydrophobicity index, and tended to attenuate the intestinal inflammation. Taurochenodeoxycholic acid significantly suppresses paw swelling and polyarthritis index, increases the loss body weight and index of thymus and spleen, and amends radiologic changes in AA rats. The overproduction and mRNA expression of TNF-α, IL-1β and IL-6 are remarkably suppressed in serum and synovium tissue of all TCDCA-treated rats.Taurochenodeoxycholic acid in dosages of 0.05 and 0.1g/kg can decrease the pulmonary coefficient in the model mice, taurochenodeoxycholic acid in dosages of 0.05 and 0.1g/kg reduce the pathological damages on their lungs; it can decrease the expression levels of TNF-α and TIMP-2 in pulmonary tissues in the pulmonary fibrosis mice, the expression level of MMP-9 increases, while it has no significant effects on MMP2.
AliasChenodeoxycholyltaurine, TCDCA, Chenyltaurine, Taurochenodeoxycholate, 12-Deoxycholyltaurine
Chemical Properties
Molecular Weight499.7
FormulaC26H45NO6S
Cas No.516-35-8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 10 mg/ml (20.01 mM)
DMSO: 50 mg/mL (100.06 mM), Sonication is recommended.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM2.0012 mL10.0060 mL20.0120 mL100.0600 mL
5 mM0.4002 mL2.0012 mL4.0024 mL20.0120 mL
10 mM0.2001 mL1.0006 mL2.0012 mL10.0060 mL
20 mM0.1001 mL0.5003 mL1.0006 mL5.0030 mL
DMSO
1mg5mg10mg50mg
50 mM0.0400 mL0.2001 mL0.4002 mL2.0012 mL
100 mM0.0200 mL0.1001 mL0.2001 mL1.0006 mL

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