Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CAY10746 is a selective Rho kinase (ROCK) inhibitor that inhibits ROCK I and ROCK II with IC50 values of 0.014 μM and 0.003 μM, respectively.CAY10746 can be used to study diabetic retinopathy.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 178.00 | |
5 mg | In stock | $ 455.00 | |
10 mg | In stock | $ 672.00 | |
25 mg | In stock | $ 1,060.00 | |
50 mg | In stock | $ 1,430.00 | |
100 mg | In stock | $ 1,920.00 | |
500 mg | In stock | $ 3,850.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 458.00 |
Description | CAY10746 is a selective Rho kinase (ROCK) inhibitor that inhibits ROCK I and ROCK II with IC50 values of 0.014 μM and 0.003 μM, respectively.CAY10746 can be used to study diabetic retinopathy. |
Targets&IC50 | ROCKI:14 nM, ROCKII:3 nM |
In vitro |
CAY10746 (0.1-10 µM) inhibits phosphorylation of the ROCK target protein MYPT1 in SH-SY5Y cells and also inhibits the migration of human umbilical vein endothelial cells (HUVECs).[1] CAY10746 (1 µM) protects isolated mouse retinal neurons from apoptosis and oxidative stress induced by high glucose in an in vitro model of diabetic retinopathy. It also promotes high glucose-induced vessel regression in mouse retinal explants.[1] CAY10746 is an inhibitor of Rho-associated kinase I (ROCK-I) and ROCK-II (IC50s = 14 and 3 nM, respectively).[1] |
Molecular Weight | 457.48 |
Formula | C26H23N3O5 |
CAS No. | 2247240-76-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 75.0 mg/mL (163.9 mM), Sonication and heating to 60℃ are recommended.
You can also refer to dose conversion for different animals. More
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CAY10746 2247240-76-0 Cell Cycle/Checkpoint Cytoskeletal Signaling Stem Cells ROCK CAY 10746 CAY-10746 inhibitor inhibit