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Butamben

Name: Butamben
Brand: TargetMol
SKU: T0916
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0916Cas No. 94-25-7

Alias Butyl 4-aminobenzoate

Butamben (Butyl 4-aminobenzoate) is a long-duration local anesthetic used for the treatment of chronic pain.

Butamben

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Purity: 99.43%

Catalog No. T0916Alias Butyl 4-aminobenzoateCas No. 94-25-7

Butamben (Butyl 4-aminobenzoate) is a long-duration local anesthetic used for the treatment of chronic pain.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
10 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.43%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Butamben AI Summary

Butamben inhibits the binding of Batrachotoxinin to high-affinity sites on voltage-dependent sodium channels, with inhibition rates of 7.0% at 10 µM and 36.8% at 100 µM. It displays a binding affinity to beta cyclodextrin with a log Ks value of 3.19. This compound modulates various biological pathways, including Lamin A splicing, mitochondrial dynamics, thyroid stimulating hormone receptor agonism, inhibition of Cytochrome P450 2C19 and activation of Cytochrome P450 3A4, amongst others. It also affects multiple blood parameters (e.g., sodium, ALT, albumin, and various blood cell counts), suggesting an influence on hematological and metabolic functions. Butamben inhibits the human BSEP with an IC50 of 181100.0 nM and shows low antiviral activity against SARS-CoV-2 in various assays, including protease inhibition (24.78% at 20 µM). Moreover, it decreases sodium fluorescein uptake in OATP1B3 and OATP1B1-transfected CHO cells at 10 µM. Additionally, the compound inhibits HDAC6, with inhibition percentages of 44.45% and 12.34% in enzymatic assays. Despite its broad range of interactions with different targets, Butamben exhibits minimal direct bioactivity in most tested concentrations (AC50 > 30000.0 nM), marking it as a compound of interest for further detailed studies..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Butamben (Butyl 4-aminobenzoate) is a long-duration local anesthetic used for the treatment of chronic pain.
Synonyms	Butyl 4-aminobenzoate

Chemical Properties

Molecular Weight	193.24
Formula	C₁₁H₁₅NO₂
Cas No.	94-25-7
Smiles	CCCCOC(=O)c1ccc(N)cc1
Relative Density.	1.078 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 36 mg/mL (186.3 mM), Sonication is recommended.

H2O: 35 mg/mL (181.12 mM), Sonication is recommended.

DMSO: 55 mg/mL (284.62 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (10.35 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	5.1749 mL	25.8746 mL	51.7491 mL	258.7456 mL
5 mM	1.0350 mL	5.1749 mL	10.3498 mL	51.7491 mL
10 mM	0.5175 mL	2.5875 mL	5.1749 mL	25.8746 mL
20 mM	0.2587 mL	1.2937 mL	2.5875 mL	12.9373 mL
50 mM	0.1035 mL	0.5175 mL	1.0350 mL	5.1749 mL
100 mM	0.0517 mL	0.2587 mL	0.5175 mL	2.5875 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc