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ARD-266

Name: ARD-266
Brand: TargetMol
SKU: T13552
Price: 637 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13552Cas No. 2666951-70-6

Alias ARD266

ARD-266 is a PROTAC degrader based on the von Hippel-Lindau E3 ligase, inducing the degradation of AR proteins, and can be used in prostate cancer research.

ARD-266

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Purity: 99.89%

Catalog No. T13552Alias ARD266Cas No. 2666951-70-6

ARD-266 is a PROTAC degrader based on the von Hippel-Lindau E3 ligase, inducing the degradation of AR proteins, and can be used in prostate cancer research.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$637	-	In Stock
5 mg	$1,380	-	In Stock
10 mg	$2,330	-	In Stock
25 mg	$3,690	-	In Stock
50 mg	$4,980	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.89%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	ARD-266 is a PROTAC degrader based on the von Hippel-Lindau E3 ligase, inducing the degradation of AR proteins, and can be used in prostate cancer research.
In vitro	ARD-266 (100 nM; 1-24 hours; LNCaP and VCaP cells) treatment effectively reduces the AR protein level within 3 h and achieves near-complete AR elimination with a 6 h treatment in the LNCaP cells. ARD-266 (1-10000 nM; 24 hours; LNCaP cells) treatment effectively suppresses the expression of PSA, TMPRSS2, and FKBP5 genes in a dose-dependent manner and is capable of reducing the mRNA levels of PSA, TMPRSS2, and FKBP5 genes by >50% at 10 nM in the LNCaP cell line.[1]
Synonyms	ARD266

Chemical Properties

Molecular Weight	915.51
Formula	C₅₂H₅₉ClN₆O₇
Cas No.	2666951-70-6
Smiles	O([C@@H]1C(C)(C)[C@@H](NC(=O)C2=CC=C(C#CC3CCN(C(C[C@H](NC(=O)[C@H]4N(C([C@H]([C@H](C)C)C=5ON=C(C)C5)=O)C[C@H](O)C4)C6=CC=CC=C6)=O)CC3)C=C2)C1(C)C)C7=CC(Cl)=C(C#N)C=C7
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (87.38 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 5 mg/mL (5.46 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0923 mL	5.4614 mL	10.9229 mL	54.6144 mL
5 mM	0.2185 mL	1.0923 mL	2.1846 mL	10.9229 mL
10 mM	0.1092 mL	0.5461 mL	1.0923 mL	5.4614 mL
20 mM	0.0546 mL	0.2731 mL	0.5461 mL	2.7307 mL
50 mM	0.0218 mL	0.1092 mL	0.2185 mL	1.0923 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc