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DL-Norepinephrine hydrochloride
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Catalog No. T13655Cas No. 55-27-6
Alias DL-lysine
DL-Norepinephrine hydrochloride (DL-lysine) is a high-affinity basic amino acid substrate of amino acid transporter b0 + with a Km value in the range of 100-400 μM.
DL-Norepinephrine hydrochloride
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Purity: 98.82%
Catalog No. T13655Alias DL-lysineCas No. 55-27-6
DL-Norepinephrine hydrochloride (DL-lysine) is a high-affinity basic amino acid substrate of amino acid transporter b0 + with a Km value in the range of 100-400 μM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 100 mg | $36 | In Stock | In Stock | |
| 500 mg | $81 | - | In Stock | |
| 1 g | $118 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $40 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:98.82%
Appearance:Solid
Color:White to Yellow
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Product Introduction
DL-Norepinephrine hydrochloride AI Summary
DL-Norepinephrine hydrochloride exhibits multifaceted bioactivity as an inhibitor across a range of biological targets and pathogens. In enzymatic assays, it inhibits the JMJD2A-Tudor Domain with a potency of 89125.1 nM, Rango-Importin beta complex formation at 125892.5 nM, HP1-beta Chromodomain interactions with methylated histone tails at 70794.6 nM, Polymerase Iota at 50118.7 nM and 47443.6 nM, Polymerase Eta at 56234.1 nM and 84921.4 nM, Polymerase Kappa at 79432.8 nM, and Marburg Virus entry into cells at 31622.8 nM. Moreover, it induces DNA re-replication in SW480 colon adenocarcinoma cells with a potency of 82.0 nM and inhibits GLP-1 Receptor Inverse Agonists at 10000.0 nM.
Furthermore, it shows inhibitory activity in the development of antimalarial drugs targeting AMA1-RON with a potency of 17782.8 nM. In microbial assays, DL-Norepinephrine hydrochloride has marginal antifungal activity against Candida albicans ATCC 90028 (4.08%) and a potentially stimulatory or non-inhibitory effect on Cryptococcus neoformans H99 ATCC 208821 (-2.98%). Its antibacterial activities include inhibitions of 0.24% against Escherichia coli ATCC 25922, 15.27% against Klebsiella pneumoniae MDR ATCC 70063, 7.4% against Pseudomonas aeruginosa ATCC 27853, 28.77% against Acinetobacter baumannii ATCC 19606, and 10.44% against Staphylococcus aureus MRSA ATCC 43300. These findings suggest that DL-Norepinephrine hydrochloride holds significant potential as a versatile inhibitor with applications across various biological and antimicrobial domains..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | DL-Norepinephrine hydrochloride (DL-lysine) is a high-affinity basic amino acid substrate of amino acid transporter b0 + with a Km value in the range of 100-400 μM. |
| Synonyms | DL-lysine |
| Molecular Weight | 205.64 |
| Formula | C8H12ClNO3 |
| Cas No. | 55-27-6 |
| Smiles | Cl.NCC(O)c1ccc(O)c(O)c1 |
| Relative Density. | 1.397g/cm3 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 240.00 mg/mL (1167.09 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween-80+45% Saline: 1 mg/mL (4.86 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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