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PROTAC ERα Degrader-6
🥰Excellent
Catalog No. T208971
PROTACERα Degrader-6 (compound A3) is an effective PROTAC degrader of ERα with an IC50 of 0.12 μM in the MCE-7 cell line. It exhibits antitumor activity and serves as a fluorescent probe with an emission wavelength of 582 nm, enabling real-time visualization of ERα protein degradation.
PROTAC ERα Degrader-6
PROTAC ERα Degrader-6
🥰Excellent
Catalog No. T208971
PROTACERα Degrader-6 (compound A3) is an effective PROTAC degrader of ERα with an IC50 of 0.12 μM in the MCE-7 cell line. It exhibits antitumor activity and serves as a fluorescent probe with an emission wavelength of 582 nm, enabling real-time visualization of ERα protein degradation.
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Product Introduction
Bioactivity
Chemical Properties
| Description | PROTACERα Degrader-6 (compound A3) is an effective PROTAC degrader of ERα with an IC50 of 0.12 μM in the MCE-7 cell line. It exhibits antitumor activity and serves as a fluorescent probe with an emission wavelength of 582 nm, enabling real-time visualization of ERα protein degradation. |
| Targets&IC50 | ERα:0.12 μM (DC50) |
| In vitro | PROTAC ERα Degrader-6 (compound A2) demonstrates significant anti-proliferative activity in MCF-7 cells with an IC50 of 0.11 μM. Additionally, PROTAC ERα Degrader-6 offers excellent fluorescence imaging capabilities at λ = 582 nm. |
| Formula | C51H56N6O8S |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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