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PD-1/PD-L1-IN-10

🥰Excellent
Catalog No. T9616Cas No. 2487550-41-2

PD-1/PD-L1-IN-10 is an orally available PD-1/PD-L1 inhibitor (IC50 value of 2.7 nM) that shows anti-tumor activity.

PD-1/PD-L1-IN-10

PD-1/PD-L1-IN-10

🥰Excellent
Purity: 99.63%
Catalog No. T9616Cas No. 2487550-41-2
PD-1/PD-L1-IN-10 is an orally available PD-1/PD-L1 inhibitor (IC50 value of 2.7 nM) that shows anti-tumor activity.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$44In StockIn Stock
5 mg$98In StockIn Stock
10 mg$172In StockIn Stock
25 mg$333In StockIn Stock
50 mg$597In StockIn Stock
100 mg$852In StockIn Stock
1 mL x 10 mM (in DMSO)$116In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.63%
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Product Introduction

Bioactivity
Description
PD-1/PD-L1-IN-10 is an orally available PD-1/PD-L1 inhibitor (IC50 value of 2.7 nM) that shows anti-tumor activity.
Targets&IC50
PD-1/PD-L1:2.7 nM
In vitro
PD-1/PD-L1-IN-10 (compound B2) effectively enhances interferon-gamma secretion in vitro in a dose-dependent manner, starting at 1 nM, without compromising the viability of Lewis lung carcinoma (LLC) cells or lymph node T-cells[1]. It significantly stabilizes PD-L1 protein levels in LLC cells within the 0-100 nM range, showing a dose-dependent effect on PD-L1 stability at 58 °C, suggesting penetration and direct interaction with PD-L1[1].
In vivo
PD-1/PD-L1-IN-10 (compound B2, 5 mg/kg, intragastric gavage) exhibits potent in vivo anticancer efficacy by effectively blocking tumor cell proliferation and inducing apoptosis in LLC tumor tissues in an LLC-bearing allograft mouse model.[1]
Chemical Properties
Molecular Weight581.62
FormulaC33H31N3O7
Cas No.2487550-41-2
SmilesCC(O)[C@H](NCc1cc(c(OCc2cccc(c2C)-c2ccccc2)cc1OCc1cccc(c1)C#N)[N+]([O-])=O)C(O)=O
Relative Density.1.35 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 100 mg/mL (171.93 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+90% Saline: 3.3 mg/mL (5.67 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7193 mL8.5967 mL17.1934 mL85.9668 mL
5 mM0.3439 mL1.7193 mL3.4387 mL17.1934 mL
10 mM0.1719 mL0.8597 mL1.7193 mL8.5967 mL
20 mM0.0860 mL0.4298 mL0.8597 mL4.2983 mL
50 mM0.0344 mL0.1719 mL0.3439 mL1.7193 mL
100 mM0.0172 mL0.0860 mL0.1719 mL0.8597 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

tumorT-lymphocytePD-L1PDL1PD-1/PD-L1-IN-10PD-1/PD-L-1-IN-10PD1/PDL1IN10PD-1/PD-L1PD1/PDL1PD-1PD1PD 1/PD L1 IN 10lungLLCLewisInhibitorinhibitIFN-γcarcinomaApoptosis
Related Tags: buy PD-1/PD-L1-IN-10 | purchase PD-1/PD-L1-IN-10 | PD-1/PD-L1-IN-10 cost | order PD-1/PD-L1-IN-10 | PD-1/PD-L1-IN-10 chemical structure | PD-1/PD-L1-IN-10 in vivo | PD-1/PD-L1-IN-10 in vitro | PD-1/PD-L1-IN-10 formula | PD-1/PD-L1-IN-10 molecular weight
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