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PD-1/PD-L1-IN-10

Name: PD-1/PD-L1-IN-10
Brand: TargetMol
SKU: T9616
Price: 44 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9616Cas No. 2487550-41-2

PD-1/PD-L1-IN-10 is an orally available PD-1/PD-L1 inhibitor (IC50 value of 2.7 nM) that shows anti-tumor activity.

PD-1/PD-L1-IN-10

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Purity: 99.63%

Catalog No. T9616Cas No. 2487550-41-2

PD-1/PD-L1-IN-10 is an orally available PD-1/PD-L1 inhibitor (IC50 value of 2.7 nM) that shows anti-tumor activity.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$44	In Stock	In Stock
5 mg	$98	In Stock	In Stock
10 mg	$172	In Stock	In Stock
25 mg	$333	In Stock	In Stock
50 mg	$597	In Stock	In Stock
100 mg	$852	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$116	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.63%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	PD-1/PD-L1-IN-10 is an orally available PD-1/PD-L1 inhibitor (IC50 value of 2.7 nM) that shows anti-tumor activity.
Targets&IC50	PD-1/PD-L1:2.7 nM
In vitro	PD-1/PD-L1-IN-10 (compound B2) effectively enhances interferon-gamma secretion in vitro in a dose-dependent manner, starting at 1 nM, without compromising the viability of Lewis lung carcinoma (LLC) cells or lymph node T-cells[1]. It significantly stabilizes PD-L1 protein levels in LLC cells within the 0-100 nM range, showing a dose-dependent effect on PD-L1 stability at 58 °C, suggesting penetration and direct interaction with PD-L1[1].
In vivo	PD-1/PD-L1-IN-10 (compound B2, 5 mg/kg, intragastric gavage) exhibits potent in vivo anticancer efficacy by effectively blocking tumor cell proliferation and inducing apoptosis in LLC tumor tissues in an LLC-bearing allograft mouse model.[1]

Chemical Properties

Molecular Weight	581.62
Formula	C₃₃H₃₁N₃O₇
Cas No.	2487550-41-2
Smiles	CC(O)[C@H](NCc1cc(c(OCc2cccc(c2C)-c2ccccc2)cc1OCc1cccc(c1)C#N)[N+]([O-])=O)C(O)=O
Relative Density.	1.35 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (171.93 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: 3.3 mg/mL (5.67 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7193 mL	8.5967 mL	17.1934 mL	85.9668 mL
5 mM	0.3439 mL	1.7193 mL	3.4387 mL	17.1934 mL
10 mM	0.1719 mL	0.8597 mL	1.7193 mL	8.5967 mL
20 mM	0.0860 mL	0.4298 mL	0.8597 mL	4.2983 mL
50 mM	0.0344 mL	0.1719 mL	0.3439 mL	1.7193 mL
100 mM	0.0172 mL	0.0860 mL	0.1719 mL	0.8597 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc