Shopping Cart

Your shopping cart is currently empty

Tpl2 Kinase Inhibitor 1

Name: Tpl2 Kinase Inhibitor 1
Brand: TargetMol
SKU: T17145
Price: 64 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T17145 Copy Product Info

Purity: 98.59%

🥰Excellent

Tpl2 Kinase Inhibitor 1 is a potent, reversible, and highly selective ATP-competitive inhibitor of Tpl2 (MAP3K8/COT) serine/threonine kinase, with an IC₅₀ of 50 nM for Tpl2 kinase inhibition. In vitro, Tpl2 Kinase Inhibitor 1 inhibits LPS-induced TNF-α release from human primary monocytes (IC₅₀ = 0.7 μM). Tpl2 Kinase Inhibitor 1 can be used in research on inflammatory responses and certain cancers.

Tpl2 Kinase Inhibitor 1

Copy Product Info

🥰Excellent

Catalog No. T17145

Cas No. 871307-18-5

Pack Size	Price	USA Stock	Global Stock
1 mg	$64	-	In Stock
5 mg	$179	-	In Stock
10 mg	$289	-	In Stock
25 mg	$546	-	In Stock
50 mg	$892	-	In Stock
100 mg	$1,450	-	In Stock
1 mL x 10 mM (in DMSO)	$198	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

Add to Cart

Add to Quotation

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

Batch Information

Select Batch

Purity:98.59%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Tpl2 Kinase Inhibitor 1 is a potent, reversible, and highly selective ATP-competitive inhibitor of Tpl2 (MAP3K8/COT) serine/threonine kinase, with an IC₅₀ of 50 nM for Tpl2 kinase inhibition. In vitro, Tpl2 Kinase Inhibitor 1 inhibits LPS-induced TNF-α release from human primary monocytes (IC₅₀ = 0.7 μM). Tpl2 Kinase Inhibitor 1 can be used in research on inflammatory responses and certain cancers.
Targets&IC50	p38:180 μM, MK2:110 μM
In vitro	Tpl2 Kinase Inhibitor 1 inhibits the production of TNF-α in human primary monocytes and human whole blood induced by lipopolysaccharide, with IC₅₀ values of 0.7 μM and 8.5 μM, respectively .[1]

Chemical Properties

Molecular Weight	404.83
Formula	C₂₁H₁₄ClFN₆
Cas No.	871307-18-5
Smiles	N#CC=1C=NC2=CN=C(C=C2C1NC3=CC=C(F)C(Cl)=C3)NCC=4C=NC=CC4
Relative Density.	1.45 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (197.61 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4702 mL	12.3509 mL	24.7017 mL	123.5086 mL
5 mM	0.4940 mL	2.4702 mL	4.9403 mL	24.7017 mL
10 mM	0.2470 mL	1.2351 mL	2.4702 mL	12.3509 mL
20 mM	0.1235 mL	0.6175 mL	1.2351 mL	6.1754 mL
50 mM	0.0494 mL	0.2470 mL	0.4940 mL	2.4702 mL
100 mM	0.0247 mL	0.1235 mL	0.2470 mL	1.2351 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Citations

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc