Powder: -20°C for 3 years | In solvent: -80°C for 1 year
HFI-419 is a potent inhibitor of insulin-regulated aminopeptidase (IRAP) with a K i value of 0.48 μM. It is utilized in research pertaining to cognitive and memory impairments, including Alzheimer's disease, brain trauma, and stroke [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | HFI-419 is a potent inhibitor of insulin-regulated aminopeptidase (IRAP) with a K i value of 0.48 μM. It is utilized in research pertaining to cognitive and memory impairments, including Alzheimer's disease, brain trauma, and stroke [1]. |
In vitro | HFI-419 effectively inhibits the Insulin-Regulated Aminopeptidase (IRAP) with a K_i value of 0.48 μM [1]. At a concentration of 1 μM, HFI-419 demonstrates a rapid decrease in presence, attributed to nonenzymatic processes, including amide hydrolysis [1]. |
In vivo | HFI-419, administered intravenously (i.v) and intraperitoneally (i.p) at doses of 2 mg/kg and 10 mg/kg, demonstrates significant brain exposure and potent inhibition of IRAP [1]. Utilized in a Sprague-Dawley rat model [1], the compound was noted for its brief apparent elimination half-life, high plasma clearance, and extensive volume of distribution, while effectively extending the apparent half-life to 4.6 hours. |
Molecular Weight | 354.36 |
Formula | C19H18N2O5 |
CAS No. | 1110650-72-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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HFI-419 1110650-72-0 inhibitor inhibit