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Anti-RAD50 Antibody (2B794)

😃Good
Catalog No. TMAB-12040

Anti-RAD50 Antibody (2B794) is a Rabbit antibody targeting RAD50. Anti-RAD50 Antibody (2B794) can be used in WB,ICC/IF.

Anti-RAD50 Antibody (2B794)

Anti-RAD50 Antibody (2B794)

😃Good
Catalog No. TMAB-12040
Anti-RAD50 Antibody (2B794) is a Rabbit antibody targeting RAD50. Anti-RAD50 Antibody (2B794) can be used in WB,ICC/IF.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 μL$1507-10 days7-10 days
50 μL$2637-10 days7-10 days
100 μL$4717-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-RAD50 Antibody (2B794) is a Rabbit antibody targeting RAD50. Anti-RAD50 Antibody (2B794) can be used in WB,ICC/IF.
Ig Type
IgG
Clone
2B794
Reactivity
Human,Mouse,Rat
Application
Recommended Dose
WB: 1:500-2000; ICC/IF: 1:50-200
Antibody Type
Monoclonal
Host SpeciesRabbit
Subcellular LocalizationNucleus. Chromosome telomere. Localizes to discrete nuclear foci after treatment with genotoxic agents.
Tissue SpecificityExpressed at very low level in most tissues, except in testis where it is expressed at higher level. Expressed in fibroblasts.
ConstructionRecombinant Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
Research BackgroundComponent of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis.The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases.
Antigen Details
Immunogen
A synthesized peptide: human RAD50
Antigen Species
Human
Gene Name
RAD50
Gene ID
Protein Name
DNA repair protein RAD50
Uniprot ID
Function
Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.
Chemical Properties
Molecular WeightTheoretical: 154 kDa. Actual: 154 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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