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Lazabemide hydrochloride

Name: Lazabemide hydrochloride
Brand: TargetMol
SKU: T5678
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5678Cas No. 103878-83-7

Alias N-(2-Aminoethyl)-5-chlor-2-pyridincarbox

Lazabemide hydrochloride (N-(2-Aminoethyl)-5-chlor-2-pyridincarbox) is a reversible and selective mao-b inhibitor(Ki:7.9nM).

Lazabemide hydrochloride

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Purity: 98.65%

Catalog No. T5678Alias N-(2-Aminoethyl)-5-chlor-2-pyridincarboxCas No. 103878-83-7

Lazabemide hydrochloride (N-(2-Aminoethyl)-5-chlor-2-pyridincarbox) is a reversible and selective mao-b inhibitor(Ki:7.9nM).

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$50	In Stock	In Stock
10 mg	$64	In Stock	In Stock
25 mg	$116	In Stock	In Stock
50 mg	$173	In Stock	In Stock
100 mg	$293	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:98.65%

Appearance:Solid

Color:Black

Resource Download

COA HNMR LCMS HPLC

Product Introduction

Lazabemide hydrochloride AI Summary

Lazabemide hydrochloride shows bioactivity in assays focused on identifying compounds that block the entry of Ebola virus, displaying activity with varying potencies, evidenced by AC50 values ranging from 0.7943 µM to 7.943 µM. Additionally, it demonstrates antiviral activity against SARS-CoV-2 by inhibiting virus-induced cytotoxicity in Caco-2 cells by 13.54% at a concentration of 10 µM after 48 hours, as determined by high content imaging. The compound also inhibits the SARS-CoV-2 3CL-Pro protease by 6.445% at a concentration of 20 µM according to a FRET assay. However, its inhibition of SARS-CoV-2 induced cytotoxicity in VERO-6 cells at a 10 µM concentration after 48 hours of exposure is reported to be -0.09%. These results indicate that Lazabemide hydrochloride has potential as an antiviral agent, warranting further study..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Lazabemide hydrochloride (N-(2-Aminoethyl)-5-chlor-2-pyridincarbox) is a reversible and selective mao-b inhibitor(Ki:7.9nM).
Targets&IC50	MAO-B:7.9 nM(ki)
Synonyms	N-(2-Aminoethyl)-5-chlor-2-pyridincarbox

Chemical Properties

Molecular Weight	236.098
Formula	C₈H₁₁Cl₂N₃O
Cas No.	103878-83-7
Smiles	Cl.NCCNC(=O)c1ccc(Cl)cn1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (169.42 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.2355 mL	21.1776 mL	42.3553 mL	211.7765 mL
5 mM	0.8471 mL	4.2355 mL	8.4711 mL	42.3553 mL
10 mM	0.4236 mL	2.1178 mL	4.2355 mL	21.1776 mL
20 mM	0.2118 mL	1.0589 mL	2.1178 mL	10.5888 mL
50 mM	0.0847 mL	0.4236 mL	0.8471 mL	4.2355 mL
100 mM	0.0424 mL	0.2118 mL	0.4236 mL	2.1178 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc