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Antitumor agent-19

Name: Antitumor agent-19
Brand: TargetMol
SKU: T10341
Price: 117 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T10341Cas No. 2379727-90-7

Antitumor agent-19 is a modulator of tumor-associated macrophages with EC50s of 17.18 μM and 18.87 μM in the RAW 264.7 cells and the BMDM cells.

Antitumor agent-19

🥰Excellent

Purity: 99.38%

Catalog No. T10341Cas No. 2379727-90-7

Antitumor agent-19 is a modulator of tumor-associated macrophages with EC50s of 17.18 μM and 18.87 μM in the RAW 264.7 cells and the BMDM cells.

Pack Size	Price	Availability
1 mg	$117	In Stock
2 mg	$175	In Stock
5 mg	$268	In Stock
10 mg	$394	In Stock
25 mg	$592	In Stock
50 mg	$828	In Stock
100 mg	$1,130	In Stock
500 mg	$2,260	In Stock
1 mL x 10 mM (in DMSO)	$322	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.38%

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COA LCMS

Product Introduction

Bioactivity

Description	Antitumor agent-19 is a modulator of tumor-associated macrophages with EC50s of 17.18 μM and 18.87 μM in the RAW 264.7 cells and the BMDM cells.
In vitro	In RAW 264.7 cells, Antitumor agent-19 (10 µM, 20 µM, or 50 µM) effectively and dose-dependently induces the expression of M1-phenotype macrophage markers including IL-1β, TNF-α, iNOS and IL-12α. Antitumor agent-19 dose-dependently repolarizes tumor-associated macrophages from M1 (anti-tumor) and M2 (pro-tumor)[1].
In vivo	In C57BL/6 female mice with lewis lung cancer cells, Antitumor agent-19 (5 mg/kg; i.p.) remarkably inhibits tumor growth. The synergy of Antitumor agent-19 with anti-PD-1 antibody shows more superior antineoplastic effects in vivo[1].

Chemical Properties

Molecular Weight	487.9
Formula	C₂₄H₂₁ClF₃N₅O
Cas No.	2379727-90-7
Smiles	N(C(NC1=CC(C(F)(F)F)=C(Cl)C=C1)=O)C2CC=3C4=C(C=CC=C4NC3CC2)C5=CN(C)N=C5
Relative Density.	1.49 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (102.48 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0496 mL	10.2480 mL	20.4960 mL	102.4800 mL
5 mM	0.4099 mL	2.0496 mL	4.0992 mL	20.4960 mL
10 mM	0.2050 mL	1.0248 mL	2.0496 mL	10.2480 mL
20 mM	0.1025 mL	0.5124 mL	1.0248 mL	5.1240 mL
50 mM	0.0410 mL	0.2050 mL	0.4099 mL	2.0496 mL
100 mM	0.0205 mL	0.1025 mL	0.2050 mL	1.0248 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc