Shopping Cart
Remove All
Your shopping cart is currently empty
NPC-15437 dihydrochloride
🥰Excellent
Catalog No. T37480Cas No. 141774-20-1
Alias NPC15437 dihydrochloride
NPC-15437 dihydrochloride is a synthetic prototype belonging to a novel structural class of protein kinase C (PKC) inhibitors. NPC 15437 potently inhibits PKC enzymatic activity and phorbol ester binding with IC50 values around 19 μM and 23 μM, respectively, without affecting cAMP-dependent or Ca2+/calmodulin-dependent kinases at concentrations up to 300 μM, thereby demonstrating selectivity for PKC and serving as an important tool compound for dissecting PKC-mediated cellular signaling mechanisms.
NPC-15437 dihydrochloride
🥰Excellent
Catalog No. T37480Alias NPC15437 dihydrochlorideCas No. 141774-20-1
NPC-15437 dihydrochloride is a synthetic prototype belonging to a novel structural class of protein kinase C (PKC) inhibitors. NPC 15437 potently inhibits PKC enzymatic activity and phorbol ester binding with IC50 values around 19 μM and 23 μM, respectively, without affecting cAMP-dependent or Ca2+/calmodulin-dependent kinases at concentrations up to 300 μM, thereby demonstrating selectivity for PKC and serving as an important tool compound for dissecting PKC-mediated cellular signaling mechanisms.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $166 | - | In Stock | |
| 5 mg | $397 | - | In Stock | |
| 10 mg | $589 | - | In Stock | |
| 25 mg | $948 | - | In Stock | |
| 50 mg | $1,270 | - | In Stock |
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Product Introduction
Bioactivity
Chemical Properties
| Description | NPC-15437 dihydrochloride is a synthetic prototype belonging to a novel structural class of protein kinase C (PKC) inhibitors. NPC 15437 potently inhibits PKC enzymatic activity and phorbol ester binding with IC50 values around 19 μM and 23 μM, respectively, without affecting cAMP-dependent or Ca2+/calmodulin-dependent kinases at concentrations up to 300 μM, thereby demonstrating selectivity for PKC and serving as an important tool compound for dissecting PKC-mediated cellular signaling mechanisms. |
| Targets&IC50 | PKC:19 μM |
| Synonyms | NPC15437 dihydrochloride |
| Molecular Weight | 511.62 |
| Formula | C25H52Cl2N4O2 |
| Cas No. | 141774-20-1 |
| Smiles | NCCCC[C@H](N)C(NCC1N(CCCC1)C(CCCCCCCCCCCC)=O)=O.Cl.Cl |
| Relative Density. | no data available |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | PBS (pH 7.2): 0.5 mg/mL (slightly soluble), Sonication is recommended. Ethanol: 2.5 mg/mL (4.89 mM), Sonication is recommended. DMF: 5 mg/mL (9.77 mM), Sonication is recommended. DMSO: 5 mg/mL (9.77 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
Ethanol/DMF/DMSO
DMF/DMSO
| |||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy NPC-15437 dihydrochloride | purchase NPC-15437 dihydrochloride | NPC-15437 dihydrochloride cost | order NPC-15437 dihydrochloride | NPC-15437 dihydrochloride chemical structure | NPC-15437 dihydrochloride formula | NPC-15437 dihydrochloride molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.