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Anti-Nuclear Matrix Protein p84 Antibody (8Q603) (Synonyms: THOC1_HUMAN, Thoc1, THOC 1, Tho1, THO complex su...)
Catalog No. TMAC-02896 Copy Product Info
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Anti-Nuclear Matrix Protein p84 Antibody (8Q603) is a Rabbit antibody targeting Nuclear Matrix Protein p84. Anti-Nuclear Matrix Protein p84 Antibody (8Q603) can be used in ICC,IHC,WB.
Anti-Nuclear Matrix Protein p84 Antibody (8Q603)
Copy Product Info🥰Excellent
Catalog No. TMAC-02896
Synonyms THOC1_HUMAN, Thoc1, THOC 1, Tho1, THO complex subunit 1, THO complex 1, Tho 1, p84N5, P84, Nuclear matrix protein p84, hTREX84, HPR1, HPR 1, Death domain containing protein p84N5
Anti-Nuclear Matrix Protein p84 Antibody (8Q603) is a Rabbit antibody targeting Nuclear Matrix Protein p84. Anti-Nuclear Matrix Protein p84 Antibody (8Q603) can be used in ICC,IHC,WB.
Anti-Nuclear Matrix Protein p84 Antibody
(8Q603)
(8Q603)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $296 | 7-10 days | 7-10 days | |
| 100 μL | $497 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
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| Description | Anti-Nuclear Matrix Protein p84 Antibody (8Q603) is a Rabbit antibody targeting Nuclear Matrix Protein p84. Anti-Nuclear Matrix Protein p84 Antibody (8Q603) can be used in ICC,IHC,WB. |
| Synonyms | THOC1_HUMAN, Thoc1, THOC 1, Tho1, THO complex subunit 1, THO complex 1, Tho 1, p84N5, P84, Nuclear matrix protein p84, hTREX84, HPR1, HPR 1, Death domain containing protein p84N5 |
| Ig Type | IgG |
| Clone | 8Q603 |
| Reactivity | Human,Mouse,Rat |
| Verified Activity | 1. Western blot analysis of Nuclear Matrix Protein p84 on different lysates using anti-Nuclear Matrix Protein p84 antibody at 1/500 dilution. Positive control:Lane 1: Hela, Lane 2: A431, Lane 3: Mouse skeletal muscle, Lane 4: PC-12. 2. Immunohistochemical analysis of paraffin-embedded rat testis tissue using anti-Nuclear Matrix Protein p84 antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded rat brain tissue using anti-Nuclear Matrix Protein p84 antibody. Counter stained with hematoxylin. 4. Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-Nuclear Matrix Protein p84 antibody. Counter stained with hematoxylin. 5. Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-Nuclear Matrix Protein p84 antibody. Counter stained with hematoxylin. 6. Immunohistochemical analysis of paraffin-embedded human lung cancer tissue using anti-Nuclear Matrix Protein p84 antibody. Counter stained with hematoxylin. 7. ICC staining Nuclear Matrix Protein p84 in HUVEC cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 8. ICC staining Nuclear Matrix Protein p84 in LOVO cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.         |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC: 1:50-200; ICC: 1:50-200 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | THOC1 (THO complex subunit 1), also known as Tho1, P84, HPR1 or P84N5, is a 657 amino acid nuclear matrix protein and is evolutionarily conserved from yeast to humans. THOC1 contains one death domain and is a component of the heteromultimeric THO/TREX (transcription/export) complex along with THOC2, THOC3, BAT1 and ALY. The THO/TREX complex is recruited to transcribed genes and travels along with RNA polymerase II (Pol II) during elongation, coupling elongating Pol II with RNA splicing and export factors. THOC1 is expressed at high levels in breast cancer cells and at relatively low levels in normal epithelia. A reduction of THOC1 in cancer cell lines results in reduced cell proliferation. This suggests that cancer cells are dependent on the high levels of THOC1 expression and therefore THOC1 may be a good target for cancer therapy. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein |
| Uniprot ID |
| Molecular Weight | Theoretical: 76 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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