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Vigabatrin

Name: Vigabatrin
Brand: TargetMol
SKU: T0128
Price: 44 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0128Cas No. 60643-86-9

Alias Vigabatrine, Sabril

Vigabatrin (Sabril), an analogue of gamma-aminobutyric acid, is an irreversible inhibitor of 4-aminobutyrate Transaminase responsible for the catabolism of γ-aminobutyric acid.

Vigabatrin

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Purity: 99.88%

Catalog No. T0128Alias Vigabatrine, SabrilCas No. 60643-86-9

Vigabatrin (Sabril), an analogue of gamma-aminobutyric acid, is an irreversible inhibitor of 4-aminobutyrate Transaminase responsible for the catabolism of γ-aminobutyric acid.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$44	In Stock	In Stock
10 mg	$65	In Stock	In Stock
25 mg	$128	In Stock	In Stock
50 mg	$218	In Stock	In Stock
100 mg	$393	In Stock	In Stock
500 mg	$939	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.88%

Color:White to Yellow

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COA HNMR LCMS

Product Introduction

Vigabatrin AI Summary

Vigabatrin exhibits a broad range of bioactivities and pharmacological properties. It demonstrates significant anticonvulsive activity in bicuculline (BIC) and picrotoxin (PCR) induced seizure tests in mice, with effective doses (ED50) of 220.0 umol.kg^-1 and 210.0 umol.kg^-1, respectively. Moreover, at a dosage of 100 mg/kg, it provides sustained protection against picrotoxin-induced convulsions. In terms of metabolism, Vigabatrin has a very short half-life of 0.005 hours at a concentration of 1 mM and a dissociation constant (pKa) of 9.5. It inhibits GABA transaminase (GABA-T) activity in vivo with an IC50 value of 41,210.0 nM and increases brain GABA levels, suggesting potential implications for regulating GABA neurotransmission in the brain. The compound also shows various activities in vitro; it inhibits gamma-aminobutyric acid aminotransferase from the pig brain with a Ki of 3200000.0 nM and a K inact rate of 0.37 min^-1, as well as rat GABA-AT with a Ki of 10,000,000.0 nM. Vigabatrin exhibits inhibitory activity against several human transporters, including BSEP, MRP2, MRP3, and MRP4, with IC50 values greater than 133000.0 nM. While it indicates moderate hepatic toxicity and potential retinotoxicity in specific test conditions, it shows no significant hepatic side effects and good aqueous solubility characteristics. Additionally, Vigabatrin demonstrates significant penetration and inhibition activities related to sodium fluorescein uptake in OATP1B1 and OATP1B3-transfected CHO cells. It has been evaluated for potential antiviral activity against SARS-CoV-2, showing some level of inhibition of virus-induced cytotoxicity and 3CL-Pro protease activity. It also shows a range of potencies in bioactivity assays against various targets, including enzymes and receptors, albeit mostly with high AC50 values, indicating relatively weak interactions. Overall, Vigabatrin has shown potential in modulating GABAergic activity and various other bioactivities, but further investigation is needed to fully understand its pharmacological profile and therapeutic potential..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Vigabatrin (Sabril), an analogue of gamma-aminobutyric acid, is an irreversible inhibitor of 4-aminobutyrate Transaminase responsible for the catabolism of γ-aminobutyric acid.
Synonyms	Vigabatrine, Sabril

Chemical Properties

Molecular Weight	129.16
Formula	C₆H₁₁NO₂
Cas No.	60643-86-9
Smiles	NC(CCC(O)=O)C=C
Relative Density.	1.108?g/mL?at 25?°C(lit.)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: < 1 mg/mL (insoluble)

H2O: 100 mg/mL (774.23 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	7.7423 mL	38.7117 mL	77.4234 mL	387.1168 mL
5 mM	1.5485 mL	7.7423 mL	15.4847 mL	77.4234 mL
10 mM	0.7742 mL	3.8712 mL	7.7423 mL	38.7117 mL
20 mM	0.3871 mL	1.9356 mL	3.8712 mL	19.3558 mL
50 mM	0.1548 mL	0.7742 mL	1.5485 mL	7.7423 mL
100 mM	0.0774 mL	0.3871 mL	0.7742 mL	3.8712 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc