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Anti-Phospho-MDC1 (Thr4) Polyclonal Antibody
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Catalog No. TMAB-10962
Anti-Phospho-MDC1 (Thr4) Polyclonal Antibody is a Rabbit antibody targeting Phospho-MDC1 (Thr4). Anti-Phospho-MDC1 (Thr4) Polyclonal Antibody can be used in WB.
Anti-Phospho-MDC1 (Thr4) Polyclonal Antibody
Anti-Phospho-MDC1 (Thr4) Polyclonal Antibody
😃Good
Catalog No. TMAB-10962
Anti-Phospho-MDC1 (Thr4) Polyclonal Antibody is a Rabbit antibody targeting Phospho-MDC1 (Thr4). Anti-Phospho-MDC1 (Thr4) Polyclonal Antibody can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $223 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Phospho-MDC1 (Thr4) Polyclonal Antibody is a Rabbit antibody targeting Phospho-MDC1 (Thr4). Anti-Phospho-MDC1 (Thr4) Polyclonal Antibody can be used in WB. |
| Ig Type | IgG |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. Note=Associated with chromatin. Relocalizes to discrete nuclear foci following DNA damage, this requires 'Ser-139' phosphorylation of H2AFX. Colocalizes with APTX at sites of DNA double-strand breaks. |
| Tissue Specificity | Highly expressed in testis. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq]. |
| Immunogen | KLH conjugated synthesised phosphopeptide: human MCSF Receptor around the phosphorylation site of Thr4 |
| Antigen Species | Human |
| Gene Name | MDC1 |
| Gene ID | |
| Protein Name | Mediator of DNA damage checkpoint protein 1 |
| Uniprot ID | |
| Function | Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1. |
| Molecular Weight | Theoretical: 227 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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