Shopping Cart

Your shopping cart is currently empty

SLC26A3-IN-2

Name: SLC26A3-IN-2
Brand: TargetMol
SKU: T74815
Price: 36 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T74815Cas No. 950348-60-4

SLC26A3-IN-2 is an orally available and highly potent inhibitor of the anion-exchange protein SLC26A3 for the study of constipation. dCMP disodium (2'2'') is a potent inhibitor of the anion-exchange protein SLC26A3.

SLC26A3-IN-2

Copy Product Info

😃Good

Purity: 99.86%

Catalog No. T74815Cas No. 950348-60-4

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$36	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.86%

Appearance:Solid

Color:White

Resource Download

COA LCMS

Product Introduction

Bioactivity

Description	SLC26A3-IN-2 is an orally available and highly potent inhibitor of the anion-exchange protein SLC26A3 for the study of constipation. dCMP disodium (2'2'') is a potent inhibitor of the anion-exchange protein SLC26A3.
Targets&IC50	SLC26A3:360 nM
In vitro	SLC26A3-IN-2 is an orally active inhibitor of the anion-exchange protein SLC26A3 with an IC50 of 360 nM. 92% inhibition of SLC26A3 was achieved when SLC26A3-IN-2 was treated for 10 min at a concentration of 10 μM. [1]
In vivo	Oral administration of 10 mg/kg SLC26A3-IN-2 significantly increased the weight of feces and the number of particles in a loperamide-induced constipation model in mice, showing its effect in increasing fecal hydration capacity in mice. [1]

Chemical Properties

Molecular Weight	368.84
Formula	C₁₉H₁₃ClN₂O₂S
Cas No.	950348-60-4
Smiles	O=C1C=C(N=C2SC=C(C=3C=CC=CC3)N12)COC=4C=CC=CC4Cl

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mg/mL (27.11 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7112 mL	13.5560 mL	27.1120 mL	135.5601 mL
5 mM	0.5422 mL	2.7112 mL	5.4224 mL	27.1120 mL
10 mM	0.2711 mL	1.3556 mL	2.7112 mL	13.5560 mL
20 mM	0.1356 mL	0.6778 mL	1.3556 mL	6.7780 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc