This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
SLC26A3-IN-2
Catalog No. T74815 CAS
950348-60-4
SLC26A3-IN-2 is an orally active compound that functions as an inhibitor of the anion exchanger protein SLC26A3, displaying an IC50 of 360 nM. This protein is a member of the solute carrier (SLC) family, specifically the SLC26 family, known for its broad anion specificity, including chloride, bicarbonate, sulfate, and oxalate. SLC26A3, also known as DRA, is typically down-regulated in adenoma and plays a crucial role in the intestinal absorption of chloride and oxalate. Moreover, mutations resulting in the loss of SLC26A3 function are linked to chloride-losing diarrhea [1].
All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
SLC26A3-IN-2 is an orally active compound that functions as an inhibitor of the anion exchanger protein SLC26A3, displaying an IC50 of 360 nM. This protein is a member of the solute carrier (SLC) family, specifically the SLC26 family, known for its broad anion specificity, including chloride, bicarbonate, sulfate, and oxalate. SLC26A3, also known as DRA, is typically down-regulated in adenoma and plays a crucial role in the intestinal absorption of chloride and oxalate. Moreover, mutations resulting in the loss of SLC26A3 function are linked to chloride-losing diarrhea [1].
Molecular Weight
368.84
Formula
C19H13ClN2O2S
CAS No.
950348-60-4
Storage
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dose Conversion
You can also refer to dose conversion for different animals.
More
Method for preparing DMSO master liquid: mg
drug pre-dissolved in μL DMSO (Master liquid concentration
mg/mL),
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL PEG300, mix and clarify, next add μL
Tween 80,mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL Corn oil,mix and clarify.
Note:
Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
Calculator
Molarity Calculator
Dilution Calculator
Reconstitution Calculation
Molecular Weight Calculator
bottom
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.