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SLC26A3-IN-2

Name: SLC26A3-IN-2
Brand: TargetMol
SKU: T74815
Price: 36 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T74815Cas No. 950348-60-4

SLC26A3-IN-2 is an orally available and highly potent inhibitor of the anion-exchange protein SLC26A3 for the study of constipation. dCMP disodium (2'2'') is a potent inhibitor of the anion-exchange protein SLC26A3.

SLC26A3-IN-2

🥰Excellent

Purity: 99.86%

Catalog No. T74815Cas No. 950348-60-4

Pack Size	Price	Availability	Quantity
1 mg	$36	In Stock

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Purity:99.86%

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COA LCMS

Product Introduction

Bioactivity

Description	SLC26A3-IN-2 is an orally available and highly potent inhibitor of the anion-exchange protein SLC26A3 for the study of constipation. dCMP disodium (2'2'') is a potent inhibitor of the anion-exchange protein SLC26A3.
Targets&IC50	SLC26A3:360 nM
In vitro	SLC26A3-IN-2 is an orally active inhibitor of the anion-exchange protein SLC26A3 with an IC50 of 360 nM. 92% inhibition of SLC26A3 was achieved when SLC26A3-IN-2 was treated for 10 min at a concentration of 10 μM. [1]
In vivo	Oral administration of 10 mg/kg SLC26A3-IN-2 significantly increased the weight of feces and the number of particles in a loperamide-induced constipation model in mice, showing its effect in increasing fecal hydration capacity in mice. [1]

Chemical Properties

Molecular Weight	368.84
Formula	C₁₉H₁₃ClN₂O₂S
Cas No.	950348-60-4
Smiles	O=C1C=C(N=C2SC=C(C=3C=CC=CC3)N12)COC=4C=CC=CC4Cl
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mg/mL (27.11 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7112 mL	13.5560 mL	27.1120 mL	135.5601 mL
5 mM	0.5422 mL	2.7112 mL	5.4224 mL	27.1120 mL
10 mM	0.2711 mL	1.3556 mL	2.7112 mL	13.5560 mL
20 mM	0.1356 mL	0.6778 mL	1.3556 mL	6.7780 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc