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Kinesore

Name: Kinesore
Brand: TargetMol
SKU: T15663
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15663Cas No. 363571-83-9

Kinesore is a cell-permeable small molecule modulator that binds primarily to the microtubule motor protein kinesin-1, thereby inhibiting the interaction between KLC2 (kinesin light chain 2) and SKIP (SKIP protein), and thus regulating the structure of the microtubule network to influence cytoskeletal organization and dynamics.

Kinesore

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Purity: 97.24%

Catalog No. T15663Cas No. 363571-83-9

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$35	In Stock	In Stock
5 mg	$56	In Stock	In Stock
10 mg	$89	In Stock	In Stock
25 mg	$162	In Stock	In Stock
50 mg	$243	In Stock	In Stock
100 mg	$365	-	In Stock
200 mg	$548	-	In Stock
1 mL x 10 mM (in DMSO)	$67	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.24%

Appearance:Solid

Color:Gray

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Kinesore is a cell-permeable small molecule modulator that binds primarily to the microtubule motor protein kinesin-1, thereby inhibiting the interaction between KLC2 (kinesin light chain 2) and SKIP (SKIP protein), and thus regulating the structure of the microtubule network to influence cytoskeletal organization and dynamics.
In vitro	In cells treated with Kinesore, the microtubule network was completely reorganized into a series of rings and bundles. Lysosomal compartments were concentrated in the juxtanuclear region, where microtubules were relatively scarce. Kinesore (50 μM) was highly permeable to cells, with 95 ± 2.4% of cells showing a reorganized non-radial microtubule network. [1]

Chemical Properties

Molecular Weight	536.17
Formula	C₂₀H₁₆Br₂N₄O₄
Cas No.	363571-83-9
Smiles	O=C(C1=CC(Br)=C(C(Br)=C1)O)NN=CC2=C(C)N(C3=CC([N+]([O-])=O)=CC=C3)C(C)=C2
Relative Density.	1.71 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (186.51 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8651 mL	9.3254 mL	18.6508 mL	93.2540 mL
5 mM	0.3730 mL	1.8651 mL	3.7302 mL	18.6508 mL
10 mM	0.1865 mL	0.9325 mL	1.8651 mL	9.3254 mL
20 mM	0.0933 mL	0.4663 mL	0.9325 mL	4.6627 mL
50 mM	0.0373 mL	0.1865 mL	0.3730 mL	1.8651 mL
100 mM	0.0187 mL	0.0933 mL	0.1865 mL	0.9325 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc