Kinesore is a cell-permeable small molecule modulator that binds primarily to the microtubule motor protein kinesin-1, thereby inhibiting the interaction between KLC2 (kinesin light chain 2) and SKIP (SKIP protein), and thus regulating the structure of the microtubule network to influence cytoskeletal organization and dynamics.

In cells treated with Kinesore, the microtubule network was completely reorganized into a series of rings and bundles. Lysosomal compartments were concentrated in the juxtanuclear region, where microtubules were relatively scarce. Kinesore (50 μM) was highly permeable to cells, with 95 ± 2.4% of cells showing a reorganized non-radial microtubule network. [1]