Anti-PAX6 Polyclonal Antibody

(Synonyms: PAX 6, Paired box protein Pax-6, Oculorhombin, Aniridia type II protein, AN2) Copy Product Info

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Synonyms: PAX 6, Paired box protein Pax-6, Oculorhombin, Aniridia type II protein, AN2

Catalog No. TMAB-01338 Copy Product Info

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Anti-PAX6 Polyclonal Antibody is a Rabbit antibody targeting PAX6. Anti-PAX6 Polyclonal Antibody can be used in FCM,WB.

Anti-PAX6 Polyclonal Antibody

Pack Size	Price	USA Stock	Global Stock
50 μL	$221	7-10 days	7-10 days
100 μL	$373	7-10 days	7-10 days
200 μL	$528	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	Anti-PAX6 Polyclonal Antibody is a Rabbit antibody targeting PAX6. Anti-PAX6 Polyclonal Antibody can be used in FCM,WB.
Synonyms	PAX 6, Paired box protein Pax-6, Oculorhombin, Aniridia type II protein, AN2
Ig Type	IgG
Reactivity	Human,Mouse,Rat (predicted:Chicken,Dog,Cow,Horse,Rabbit,Sheep)

Application	FCM WB
Recommended Dose	WB: 1:500-2000; FCM: 1ug/Test
Antibody Type	Polyclonal
Host Species	Rabbit
Subcellular Localization	Nucleus.
Tissue Specificity	Fetal eye, brain, spinal cord and olfactory epithelium. Isoform 5a is less abundant than the PAX6 shorter form.
Construction	Polyclonal Antibody
Purification	Protein A purified
Appearance	Liquid
Formulation	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration	1 mg/mL
Research Background	Pax genes contain paired domains with strong homology to genes in Drosophila which are involved in programming early development. The PAX2 gene is expressed in primitive cells of the kidney, ureter, eye, ear, and central nervous system. More specifically, in human embryo sections, PAX2 is expressed in the optic vesicle and later in the retina, in the otic vesicle and later in the semicircular canals of the inner ear, and in mesonephros, metanephros, adrenals, spinal cord, and hindbrain. PAX2 mutations can be responsible for renal hypoplasia, either isolated or associated with various ophthalmologic manifestations ranging from retinal coloboma to microphthalmia. The gene which encodes Pax-2 maps to human chromosome 10q24.3-q25.1. Lesions in the PAX6 gene accounts for most cases of aniridia, a congenital malformation of the eye, chiefly characterized by iris hypoplasia, which can cause blindness. PAX6 is involved in other anterior segment malformations besides aniridia, such as Peters anomaly, a major error in the embryonic development of the eye with corneal clouding with variable iridolenticulocorneal adhesions. The gene which encodes Pax-6 maps to human chromosome 11p13.

Antigen Details

Immunogen	KLH conjugated synthetic peptide: human PAX6
Antigen Species	Human
Gene Name	PAX6
Gene ID	5080
Protein Name	Paired box protein Pax-6
Uniprot ID	P26367
Biology Area	Ectoderm,Endoderm,Pancreas development,PAX,Neural Stem Cell marker,Neural Signal Transduction,Ectoderm,Endoderm
Function	Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes.

Chemical Properties

Molecular Weight

Theoretical: 46 kDa. Actual: 50 kDa.

Stability & Storage

Stability & Storage	Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
Transport	Shipping with blue ice.

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