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Eupatilin (Alias: NSC 122413)

Name: Eupatilin
Brand: TargetMol
SKU: T3362
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T3362 Copy Product Info

Purity: 99.54%

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Eupatilin (NSC-122413), a flavone derived from Artemisia princepsPampanini, is a PPARα agonist, with pharmacological activity.

Eupatilin

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Catalog No. T3362

Alias NSC 122413

Eupatilin (NSC-122413), a flavone derived from Artemisia princepsPampanini, is a PPARα agonist, with pharmacological activity.

Cas No. 22368-21-4

Pack Size	Price	USA Stock	Global Stock
10 mg	$31	In Stock	In Stock
25 mg	$64	In Stock	In Stock
50 mg	$106	In Stock	In Stock
100 mg	$169	-	In Stock
1 mL x 10 mM (in DMSO)	$35	In Stock	In Stock

In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.54%

Color:White to Yellow

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COA HNMR LCMS

Product Introduction

Eupatilin AI Summary

Eupatilin exhibits a multifaceted bioactivity profile. It shows in vitro cytotoxic potency against various human tumor cell lines, including NCI-60 with a GI50 of 15000.0 nM, and specific antiproliferative activities against SNU638, SNU601, SNU484, AGS, and MKN1 cells with IC50 values of 50000.0 nM. Moreover, it induces significant apoptosis in U87MG cells and exerts antiproliferative effects on HL60 cells. The compound also demonstrates inhibitory activity against tubulin polymerization and colchicine binding to tubulin, suggesting potential impacts on cellular structure and function. In the context of receptor activity, Eupatilin acts as a delta opioid receptor antagonist (Ki = 12000.0 nM) and mu opioid receptor antagonist (Ki = 28000.0 nM), with a notable selectivity ratio favoring delta receptor binding. Additionally, it shows varying affinities for mu, delta, and kappa opioid receptors, while exhibiting low activity towards cannabinoid receptors CB1 and CB2. Beyond its oncological potential, Eupatilin displays antiviral capabilities against SARS-CoV-2, including inhibiting virus-induced cytotoxicity in Caco-2 and Vero-6 cells, and demonstrating activity against the viral protease 3CL-Pro. This compound also downregulates VEGF and HIF-1 alpha protein levels, inhibits Akt phosphorylation, and displays antiangiogenic activities, further contributing to its broad-spectrum biological effects. In immunological assessments, Eupatilin functions as an immunosuppressant by inhibiting T lymphocyte proliferation with an IC50 of 11700.0 nM. Furthermore, it shows high inhibitory activity against HDAC6 in enzymatic assays and significant AKT inhibition in mutant melanoma cells, highlighting its potential in targeted cancer therapies..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Eupatilin (NSC-122413), a flavone derived from Artemisia princepsPampanini, is a PPARα agonist, with pharmacological activity.
Synonyms	NSC 122413

Chemical Properties

Molecular Weight	344.32
Formula	C₁₈H₁₆O₇
Cas No.	22368-21-4
Smiles	COc1ccc(cc1OC)-c1cc(=O)c2c(O)c(OC)c(O)cc2o1
Relative Density.	1.387 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 62 mg/mL (180.07 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.81 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9043 mL	14.5214 mL	29.0428 mL	145.2138 mL
5 mM	0.5809 mL	2.9043 mL	5.8086 mL	29.0428 mL
10 mM	0.2904 mL	1.4521 mL	2.9043 mL	14.5214 mL
20 mM	0.1452 mL	0.7261 mL	1.4521 mL	7.2607 mL
50 mM	0.0581 mL	0.2904 mL	0.5809 mL	2.9043 mL
100 mM	0.0290 mL	0.1452 mL	0.2904 mL	1.4521 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc