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SB 258719

Name: SB 258719
Brand: TargetMol
SKU: T12855
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T12855Cas No. 195199-95-2

SB 258719 is a selective antagonist of 5-HT7 receptor with pKi of 7.5.

SB 258719

🥰Excellent

Purity: 99.73%

Catalog No. T12855Cas No. 195199-95-2

SB 258719 is a selective antagonist of 5-HT7 receptor with pKi of 7.5.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	-	In Stock
5 mg	$50	-	In Stock
10 mg	$82	-	In Stock
25 mg	$166	-	In Stock
50 mg	$267	-	In Stock
100 mg	$395	-	In Stock
200 mg	$557	-	In Stock
1 mL x 10 mM (in DMSO)	$56	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.73%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	SB 258719 is a selective antagonist of 5-HT7 receptor with pKi of 7.5.
Targets&IC50	5-HT7 receptor:7.5 (pKi)
In vitro	SB 258719 antagonised surmountably 5-CT-stimulated adenylyl cyclase activity. Schild analysis of the antagonism by SB 258719 gave a pA2 of 7.2±0.2 and slope not significantly different from 1, consistent with competitive antagonism[3].
In vivo	SB 258719 (5-20 mg/kg, i.p.) reversed the hypothermic effect of 5-CT in mice[1], attenuated increased Wnt/β-catenin activity in HCC cell lines and patient-derived primary tumor tissues in the presence of 5-HT, and reduced tumor growth in vivo[2].

Chemical Properties

Molecular Weight	338.51
Formula	C₁₈H₃₀N₂O₂S
Cas No.	195199-95-2
Smiles	C[C@H](CCN1CCC(C)CC1)N(C)S(=O)(=O)c1cccc(C)c1
Relative Density.	1.075 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (738.53 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (14.77 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9541 mL	14.7706 mL	29.5412 mL	147.7061 mL
5 mM	0.5908 mL	2.9541 mL	5.9082 mL	29.5412 mL
10 mM	0.2954 mL	1.4771 mL	2.9541 mL	14.7706 mL
20 mM	0.1477 mL	0.7385 mL	1.4771 mL	7.3853 mL
50 mM	0.0591 mL	0.2954 mL	0.5908 mL	2.9541 mL
100 mM	0.0295 mL	0.1477 mL	0.2954 mL	1.4771 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc