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SB 258719

Name: SB 258719
Brand: TargetMol
SKU: T12855
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12855Cas No. 195199-95-2

SB 258719 is a selective antagonist of 5-HT7 receptor with pKi of 7.5.

SB 258719

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Purity: 99.73%

Catalog No. T12855Cas No. 195199-95-2

SB 258719 is a selective antagonist of 5-HT7 receptor with pKi of 7.5.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	-	In Stock
5 mg	$50	-	In Stock
10 mg	$82	-	In Stock
25 mg	$166	-	In Stock
50 mg	$267	-	In Stock
100 mg	$395	-	In Stock
200 mg	$557	-	In Stock
1 mL x 10 mM (in DMSO)	$56	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.73%

Appearance:Solid

Color:Transparent

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	SB 258719 is a selective antagonist of 5-HT7 receptor with pKi of 7.5.
Targets&IC50	5-HT7 receptor:7.5 (pKi)
In vitro	SB 258719 antagonised surmountably 5-CT-stimulated adenylyl cyclase activity. Schild analysis of the antagonism by SB 258719 gave a pA2 of 7.2±0.2 and slope not significantly different from 1, consistent with competitive antagonism[3].
In vivo	SB 258719 (5-20 mg/kg, i.p.) reversed the hypothermic effect of 5-CT in mice[1], attenuated increased Wnt/β-catenin activity in HCC cell lines and patient-derived primary tumor tissues in the presence of 5-HT, and reduced tumor growth in vivo[2].

Chemical Properties

Molecular Weight	338.51
Formula	C₁₈H₃₀N₂O₂S
Cas No.	195199-95-2
Smiles	C[C@H](CCN1CCC(C)CC1)N(C)S(=O)(=O)c1cccc(C)c1
Relative Density.	1.075 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (738.53 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (14.77 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9541 mL	14.7706 mL	29.5412 mL	147.7061 mL
5 mM	0.5908 mL	2.9541 mL	5.9082 mL	29.5412 mL
10 mM	0.2954 mL	1.4771 mL	2.9541 mL	14.7706 mL
20 mM	0.1477 mL	0.7385 mL	1.4771 mL	7.3853 mL
50 mM	0.0591 mL	0.2954 mL	0.5908 mL	2.9541 mL
100 mM	0.0295 mL	0.1477 mL	0.2954 mL	1.4771 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc