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α-Tocopherol phosphate
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Catalog No. T17304Cas No. 38976-17-9
Alias vitamin E phosphate, TocP, alpha-Tocopherol phosphate
α-Tocopherol phosphate disodium salt is a water-soluble derivative of vitamin E that functions as an antioxidant, protecting rat hippocampal neurons against oxidative stress. α-Tocopherol phosphate disodium salt is also used to investigate molecular mechanisms of cellular protection and membrane transport, providing insights into neuroprotection and redox biology.
α-Tocopherol phosphate
😃Good
Catalog No. T17304Alias vitamin E phosphate, TocP, alpha-Tocopherol phosphateCas No. 38976-17-9
α-Tocopherol phosphate disodium salt is a water-soluble derivative of vitamin E that functions as an antioxidant, protecting rat hippocampal neurons against oxidative stress. α-Tocopherol phosphate disodium salt is also used to investigate molecular mechanisms of cellular protection and membrane transport, providing insights into neuroprotection and redox biology.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $30 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | α-Tocopherol phosphate disodium salt is a water-soluble derivative of vitamin E that functions as an antioxidant, protecting rat hippocampal neurons against oxidative stress. α-Tocopherol phosphate disodium salt is also used to investigate molecular mechanisms of cellular protection and membrane transport, providing insights into neuroprotection and redox biology. |
| In vitro | In the high glucose (Glucose)/ischemia-induced endothelial progenitor cell injury model, treatment with α-Tocopherol phosphate (100 μM) for 24 hours can inhibit the apoptosis process and migration ability of cells. It can also promote the formation of capillary-like tubes by regulating the expression levels of Bcl-2, Akt, NF-κB, p38MAPK, and JNK [2]. |
| In vivo | In the rat type 2 diabetes mellitus and ischemia model induced by Streptozotocin combined with ligation, a single intramuscular injection of 100 μM α-Tocopherol phosphate promotes angiogenesis [2]. |
| Synonyms | vitamin E phosphate, TocP, alpha-Tocopherol phosphate |
| Molecular Weight | 510.69 |
| Formula | C29H51O5P |
| Cas No. | 38976-17-9 |
| Smiles | CC1=C2C(=C(C)C(OP(=O)(O)O)=C1C)CC[C@](CCC[C@@H](CCC[C@@H](CCCC(C)C)C)C)(C)O2 |
| Relative Density. | 1.040 g/cm3 (Predicted) |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: ≥ 80 mg/mL, Sonication is recommended. H2O: < 1 mg/mL (insoluble) |
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (6.46 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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