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PB28 dihydrochloride

Name: PB28 dihydrochloride
Brand: TargetMol
SKU: T23122
Price: 399 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23122Cas No. 172907-03-8

Alias PB 28 dihydrochloride

PB28 dihydrochloride is a selective and potent sigma 2 (σ2) receptor agonist and σ1 receptor antagonist with anti-SARS-CoV-2 activity and anti-tumor activity, which inhibits cell proliferation and invasion and suppresses SKF by modulating the PI3K-AKT-mTOR signaling pathway in renal cancer. It inhibits cell proliferation and invasion by regulating the PI3K-AKT-mTOR signaling pathway in renal cancer, inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells, and induces non-caspase-dependent apoptosis.

PB28 dihydrochloride

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Purity: 99.97%

Catalog No. T23122Alias PB 28 dihydrochlorideCas No. 172907-03-8

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 mg	$399	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.97%

Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	PB28 dihydrochloride is a selective and potent sigma 2 (σ2) receptor agonist and σ1 receptor antagonist with anti-SARS-CoV-2 activity and anti-tumor activity, which inhibits cell proliferation and invasion and suppresses SKF by modulating the PI3K-AKT-mTOR signaling pathway in renal cancer. It inhibits cell proliferation and invasion by regulating the PI3K-AKT-mTOR signaling pathway in renal cancer, inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells, and induces non-caspase-dependent apoptosis.
Targets&IC50	MCF-7/ADR cells:15 nM, MCF-7/ADR cells:0.17 nM (Ki), MCF-7 cells:0.28 nM (Ki), MCF-7 cells:25 nM
In vitro	PB28 dihydrochloride has a higher affinity for the σ2 receptor, with Ki values of 0.28 nM and 0.17 nM in MCF7 and MCF7 ADR cells, respectively.Accumulation of the two types of cells in the G0-G1 phase was observed after treatment of MCF7 and MCF7 ADR cells for 24-48 h at concentrations of 15-25 nM, an effect that was not affected by time and concentration changes. and concentration changes. After 2 days of incubation, PB28 dihydrochloride effectively inhibited the growth of MCF7 and MCF7 ADR cells with IC50s of 25 nM and 15 nM, respectively.This compound triggers apoptosis through a non-cysteoaspartase-dependent pathway. In addition, PB28 dihydrochloride significantly reduced P-gp expression in a concentration- and time-dependent manner by approximately 60% in MCF7 cells and 90% in MCF7 ADR cells. PB28 dihydrochloride also exhibited significant antiproliferative toxicity in the C6 rat glioma cell line and the SK-N-SH human neuroblastoma cell line. [1]
In vivo	PB28 dihydrochloride was injected daily intraperitoneally at a concentration of 10.7 mg/mL for two weeks into C57BL/6 female mice and was shown to be effective in inhibiting tumor growth in Panc02 tumor-loaded mice. In addition, PB28 dihydrochloride significantly increased the survival rate of mice. [2]
Synonyms	PB 28 dihydrochloride

Chemical Properties

Molecular Weight	443.49
Formula	C₂₄H₄₀Cl₂N₂O
Cas No.	172907-03-8
Smiles	COC1=CC=CC2=C1CCCC2CCCN3CCN(C4CCCCC4)CC3.Cl.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 4 mg/mL (9.02 mM), Sonication is recommended.

H2O: 5 mg/mL (11.27 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.25 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.2548 mL	11.2742 mL	22.5484 mL	112.7421 mL
5 mM	0.4510 mL	2.2548 mL	4.5097 mL	22.5484 mL

H2O

	1mg	5mg	10mg	50mg
10 mM	0.2255 mL	1.1274 mL	2.2548 mL	11.2742 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc