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PROTAC PARP1 degrader

Name: PROTAC PARP1 degrader
Brand: TargetMol
SKU: T13845
Rating: 4.5 (1 reviews)

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Catalog No. T13845Cas No. 2369022-68-2

PROTAC PARP1 degrader is a targeted protein degrader of PARP1 developed using PROTAC technology, and at 10 μM for 24 hours inhibits the proliferation of the MDA-MB-231 breast cancer cell line with an IC50 of 6.12 μM, providing a powerful research tool for studying DNA damage response, PARP1 biology, and degradation-based cancer therapeutics.

PROTAC PARP1 degrader

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Catalog No. T13845Cas No. 2369022-68-2

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$1,028	7-10 days	7-10 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	PROTAC PARP1 degrader is a targeted protein degrader of PARP1 developed using PROTAC technology, and at 10 μM for 24 hours inhibits the proliferation of the MDA-MB-231 breast cancer cell line with an IC50 of 6.12 μM, providing a powerful research tool for studying DNA damage response, PARP1 biology, and degradation-based cancer therapeutics.
Targets&IC50	MDA-MB-231 cells cell line:8.45 μM
In vitro	In MDA-MB-231 breast cancer cells, PROTAC PARP1 degrader exhibits antiproliferative activity with an IC₅₀ of 8.45 μM after 24 hours of incubation [1][2].

Chemical Properties

Molecular Weight	1145.1
Formula	C₅₈H₆₃Cl₂N₁₁O₁₀
Cas No.	2369022-68-2
Smiles	C(=O)(N1[C@H]([C@H](N=C1C2=C(OC(C)C)C=C(OC)C=C2)C3=CC=C(Cl)C=C3)C4=CC=C(Cl)C=C4)N5CC(=O)N(CC(NCCOCCOCCOCCOCCN6C=C(N=N6)C7=CC=C(C=C7)N8N=C9C(=C8)C=CC=C9C(N)=O)=O)CC5
Relative Density.	1.39 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (69.86 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.8733 mL	4.3664 mL	8.7329 mL	43.6643 mL
5 mM	0.1747 mL	0.8733 mL	1.7466 mL	8.7329 mL
10 mM	0.0873 mL	0.4366 mL	0.8733 mL	4.3664 mL
20 mM	0.0437 mL	0.2183 mL	0.4366 mL	2.1832 mL
50 mM	0.0175 mL	0.0873 mL	0.1747 mL	0.8733 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc