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PROTAC PARP1 degrader

Name: PROTAC PARP1 degrader
Brand: TargetMol
SKU: T13845
Rating: 4.5 (1 reviews)

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Catalog No. T13845Cas No. 2369022-68-2

PROTAC PARP1 degrader is a targeted protein degrader of PARP1 developed using PROTAC technology, and at 10 μM for 24 hours inhibits the proliferation of the MDA-MB-231 breast cancer cell line with an IC50 of 6.12 μM, providing a powerful research tool for studying DNA damage response, PARP1 biology, and degradation-based cancer therapeutics.

PROTAC PARP1 degrader

😃Good

Catalog No. T13845Cas No. 2369022-68-2

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$1,028	7-10 days	7-10 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	PROTAC PARP1 degrader is a targeted protein degrader of PARP1 developed using PROTAC technology, and at 10 μM for 24 hours inhibits the proliferation of the MDA-MB-231 breast cancer cell line with an IC50 of 6.12 μM, providing a powerful research tool for studying DNA damage response, PARP1 biology, and degradation-based cancer therapeutics.
Targets&IC50	MDA-MB-231:8.45 μM
In vitro	In MDA-MB-231 breast cancer cells, PROTAC PARP1 degrader exhibits antiproliferative activity with an IC₅₀ of 8.45 μM after 24 hours of incubation [1][2].

Chemical Properties

Molecular Weight	1145.1
Formula	C₅₈H₆₃Cl₂N₁₁O₁₀
Cas No.	2369022-68-2
Smiles	C(=O)(N1[C@H]([C@H](N=C1C2=C(OC(C)C)C=C(OC)C=C2)C3=CC=C(Cl)C=C3)C4=CC=C(Cl)C=C4)N5CC(=O)N(CC(NCCOCCOCCOCCOCCN6C=C(N=N6)C7=CC=C(C=C7)N8N=C9C(=C8)C=CC=C9C(N)=O)=O)CC5
Relative Density.	1.39 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (69.86 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.8733 mL	4.3664 mL	8.7329 mL	43.6643 mL
5 mM	0.1747 mL	0.8733 mL	1.7466 mL	8.7329 mL
10 mM	0.0873 mL	0.4366 mL	0.8733 mL	4.3664 mL
20 mM	0.0437 mL	0.2183 mL	0.4366 mL	2.1832 mL
50 mM	0.0175 mL	0.0873 mL	0.1747 mL	0.8733 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

The above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc