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NOD1/2 antagonist-1
🥰Excellent
Catalog No. T72473Cas No. 2704623-69-6
NOD1/2 antagonist-1 is a dual inhibitor of nucleotide-binding oligomerization domain-like receptors NOD1 and NOD2, exhibiting IC50 values of 1.13 uM for NOD1 and 0.77 uM for NOD2, with an acceptable half-life of 67.6 minutes. NOD1/2 antagonist-1 enhances the antitumor efficacy of paclitaxel and serves as a potent experimental tool for investigating innate immune receptor-mediated signaling and cancer therapy modulation.
NOD1/2 antagonist-1
🥰Excellent
Purity: 99.69%
Catalog No. T72473Cas No. 2704623-69-6
NOD1/2 antagonist-1 is a dual inhibitor of nucleotide-binding oligomerization domain-like receptors NOD1 and NOD2, exhibiting IC50 values of 1.13 uM for NOD1 and 0.77 uM for NOD2, with an acceptable half-life of 67.6 minutes. NOD1/2 antagonist-1 enhances the antitumor efficacy of paclitaxel and serves as a potent experimental tool for investigating innate immune receptor-mediated signaling and cancer therapy modulation.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $490 | - | In Stock | |
| 5 mg | $1,130 | - | In Stock | |
| 10 mg | $1,530 | - | In Stock | |
| 25 mg | $2,270 | - | In Stock | |
| 50 mg | $2,980 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.69%
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Product Introduction
Bioactivity
Chemical Properties
| Description | NOD1/2 antagonist-1 is a dual inhibitor of nucleotide-binding oligomerization domain-like receptors NOD1 and NOD2, exhibiting IC50 values of 1.13 uM for NOD1 and 0.77 uM for NOD2, with an acceptable half-life of 67.6 minutes. NOD1/2 antagonist-1 enhances the antitumor efficacy of paclitaxel and serves as a potent experimental tool for investigating innate immune receptor-mediated signaling and cancer therapy modulation. |
| Targets&IC50 | NOD2:0.77 μM, NOD1:1.13 μM |
| In vitro | NOD1/2 antagonist-1 (0-10 μM, 3 hours) can inhibit C12-iE-DAP-induced or MDP-induced NF-κB activation [1]. NOD1/2 antagonist-1 (0-10 μM, 1 hour) suppresses inflammatory responses by activating NOD1 and NOD2 [1]. NOD1/2 antagonist-1 (0-10 μM, 1 hour) sustainably and dose-dependently reduces the transcriptional levels of IL-6, TNF-α, and IL-8 [1]. |
| In vivo | In the B16 tumor-bearing model, NOD1/2 antagonist-1 (50 mg/kg, intravenous injection, once every other day for 16 days) significantly enhanced the anti-tumor effect of paclitaxel (PTX) [1]. |
| Molecular Weight | 663.03 |
| Formula | C32H28ClF5N4O4 |
| Cas No. | 2704623-69-6 |
| Smiles | O=C(NCCCOC1=CC=C(C=C1)C(F)(F)F)C2=CC=3N=CN(C(=O)C3C=C2C=4C=CC=C(Cl)C4)CC(=O)N5CCCC(F)(F)C5 |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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