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NOD1/2 antagonist-1
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Catalog No. T72473Cas No. 2704623-69-6
NOD1/2 antagonist-1 is a dual inhibitor of nucleotide-binding oligomerization domain-like receptors NOD1 and NOD2, exhibiting IC50 values of 1.13 uM for NOD1 and 0.77 uM for NOD2, with an acceptable half-life of 67.6 minutes. NOD1/2 antagonist-1 enhances the antitumor efficacy of paclitaxel and serves as a potent experimental tool for investigating innate immune receptor-mediated signaling and cancer therapy modulation.
NOD1/2 antagonist-1
😃Good
Purity: 99.69%
Catalog No. T72473Cas No. 2704623-69-6
NOD1/2 antagonist-1 is a dual inhibitor of nucleotide-binding oligomerization domain-like receptors NOD1 and NOD2, exhibiting IC50 values of 1.13 uM for NOD1 and 0.77 uM for NOD2, with an acceptable half-life of 67.6 minutes. NOD1/2 antagonist-1 enhances the antitumor efficacy of paclitaxel and serves as a potent experimental tool for investigating innate immune receptor-mediated signaling and cancer therapy modulation.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $490 | - | In Stock | |
| 5 mg | $1,130 | - | In Stock | |
| 10 mg | $1,530 | - | In Stock | |
| 25 mg | $2,270 | - | In Stock | |
| 50 mg | $2,980 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.69%
Appearance:Solid
Color:White
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | NOD1/2 antagonist-1 is a dual inhibitor of nucleotide-binding oligomerization domain-like receptors NOD1 and NOD2, exhibiting IC50 values of 1.13 uM for NOD1 and 0.77 uM for NOD2, with an acceptable half-life of 67.6 minutes. NOD1/2 antagonist-1 enhances the antitumor efficacy of paclitaxel and serves as a potent experimental tool for investigating innate immune receptor-mediated signaling and cancer therapy modulation. |
| Targets&IC50 | NOD2:0.77 μM, NOD1:1.13 μM |
| In vitro | NOD1/2 antagonist-1 (0-10 μM, 3 hours) can inhibit C12-iE-DAP-induced or MDP-induced NF-κB activation [1]. NOD1/2 antagonist-1 (0-10 μM, 1 hour) suppresses inflammatory responses by activating NOD1 and NOD2 [1]. NOD1/2 antagonist-1 (0-10 μM, 1 hour) sustainably and dose-dependently reduces the transcriptional levels of IL-6, TNF-α, and IL-8 [1]. |
| In vivo | In the B16 tumor-bearing model, NOD1/2 antagonist-1 (50 mg/kg, intravenous injection, once every other day for 16 days) significantly enhanced the anti-tumor effect of paclitaxel (PTX) [1]. |
| Molecular Weight | 663.03 |
| Formula | C32H28ClF5N4O4 |
| Cas No. | 2704623-69-6 |
| Smiles | O=C(NCCCOC1=CC=C(C=C1)C(F)(F)F)C2=CC=3N=CN(C(=O)C3C=C2C=4C=CC=C(Cl)C4)CC(=O)N5CCCC(F)(F)C5 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 25 mg/mL (37.71 mM), Sonication is recommended.  H2O: < 1 mg/mL (insoluble), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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