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STING

Stimulator of interferon genes (STING), also known as transmembrane protein 173 (TMEM173) and MPYS/MITA/ERIS is a protein that in humans is encoded by the STING1 gene. STING plays an important role in innate immunity. STING induces type I interferon production when cells are infected with intracellular pathogens, such as viruses, mycobacteria and intracellular parasites. Type I interferon, mediated by STING, protects infected cells and nearby cells from local infection by binding to the same cell that secretes it (autocrine signaling) and nearby cells (paracrine signaling.) It thus plays an important role, for instance, in controlling norovirus infection. STING works as both a direct cytosolic DNA sensor (CDS) and an adaptor protein in Type I interferon signaling through different molecular mechanisms. It has been shown to activate downstream transcription factors STAT6 and IRF3 through TBK1, which are responsible for antiviral response and innate immune response against intracellular pathogen.

  • Vadimezan
    T6273117570-53-3
    Vadimezan (DMXAA) is a vascular disrupting agent, a murine STING agonist, and an inducer of cytokines such as type I IFN. Vadimezan has antitumor activity and induces a rapid cessation of blood flow in tumors without affecting blood flow in normal tissues.
    • $48
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  • ADU-S100 ammonium salt
    T10252L21638750-96-5
    ADU-S100 ammonium salt (ML RR-S2 CDA ammonium salt) is an activator of stimulator of interferon genes (STING). ADU-S100 ammonium salt leads to potent and systemic tumor regression and immunity.
    • $159
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  • Omaveloxolone
    T69191474034-05-3
    Omaveloxolone (RTA-408) (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-κB signaling. Phase 2.
    • $38
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  • Dazostinag disodium
    T724822553413-93-5In house
    Dazostinag disodium (TAK-676) is a novel stimulator of interferon genes (STING) agonist and immune system modulator with antitumor activity that activates dendritic cells, natural killer cells, and T cells.
    • $1,650 TargetMol
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  • MSA-2
    T8798129425-81-6
    MSA-2 is a potent and orally available non-nucleotide STING agonist.
    • $34
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  • C-176
    T5154314054-00-7
    C-176 (STING inhibitor 1) is a strong, covalent mouse STING inhibitor
    • $39
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  • H-151
    T5674941987-60-6
    H-151 is a highly potent and selective STING antagonist. H-151 covalently binds to Cys91 of STING and inhibits palmitoylation of Cys91, thereby inhibiting STING activity. H-151 can be used in the study of autoinflammatory diseases in vivo and ex vivo.
    • $30
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  • SR-717
    T86552375421-09-1
    SR-717 is a cGAMP analog, a non-nucleoside STING agonist that induces a closed activation conformation of STING. SR-717 has antitumor activity and promotes activation of immune cells and cross-presentation of antigens.
    • $75
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  • diABZI STING agonist-1 (Tautomerism)
    T110352138498-18-5
    diABZI STING agonist-1 (Tautomerism) (diABZI STING agonist (Compound 3)) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively.
    • $168
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  • 2',3'-cGAMP sodium
    T10065L2734858-36-5
    2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium) is a second messenger in cellular innate immunity and is catalyzed by cGAMP synthase (cGAS) under DNA binding conditions. 2',3'-cGAMP sodium binds to STING to form a dimer, inducing the production and expression of interferon-β and other cytokines.
    • $298
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  • Cyclic-di-GMP disodium
    T369832222132-40-1
    Cyclic-di-GMP disodium (5GP-5GP disodium) is a bacterial second messenger and a STING agonist involved in a variety of prokaryotic processes including biofilm formation, motility, and cell cycle progression.Cyclic-di-GMP disodium displays antiproliferative activity against cancer cells, inducing elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP disodium can be used in cancer research cancer.
    • $139
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  • STING (WT/R232) activity regulator 126
    T60000702662-64-4
    STING (WT/R232) activity regulator 126 is a STING modulator with antibacterial and antiviral effects.
    • $195
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  • STING agonist-30
    T748092951078-67-2In house
    STING agonist-30 is a potent STING agonist that triggers STING-dependent immune activation.STING agonist-30 shows broad-spectrum inhibitory effects against a variety of viruses including HSV (Herpes Simplex Virus), rotavirus, and SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2).
    • $293 TargetMol
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  • SN-008
    T95542249106-01-0In house
    SN-008 is a less active analog SN-011 which is a STING antagonist. SN-008 can be used as a negative control.
    • $56
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  • diABZI STING agonist-1 trihydrochloride
    T55162138299-34-8
    diABZI STING agonist-1 (trihydrochloride) is stimulator of interferon genes (STING) receptor agonist.
    • $175
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  • STING agonist-1
    T8328702662-50-8
    STING agonist-1 (G10) is a human-specific STING agonist,elicits antiviral activity against emerging Alphaviruses.
    • $31
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  • 2',3'-cGAMP
    T100651441190-66-4
    2',3'-cGAMP (2'-3'-cyclic GMP-AMP) is a second messenger in cellular innate immunity and is catalyzed by cGAMP synthase (cGAS) under DNA binding conditions. 2',3'-cGAMP binds to STING to form a dimer, inducing the production and expression of interferon-β and other cytokines.
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    • CCCP
      T7081555-60-2
      CCCP (Carbonyl Cyanide m-Chlorophenylhydrazone) is an oxidative phosphorylation (OXPHOS) inhibitor and mitochondrial proton carrier uncoupler. CCCP inhibits the activation of STING and its downstream signaling molecules TBK1 and IRF3.
      • $41
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    • C-di-IMP disodium
      T82760
      C-di-IMP disodium, a STING agonist, is utilized in tumor research [1].
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    • Anti-inflammatory agent 65
      T830473035442-58-8
      Anti-inflammatory agent 65 (compound 29), a Hederagonic acid derivative, exhibits potent activity by inhibiting nitric oxide (NO) release, nuclear translocation of IRF3 and p65, and disrupting the STING/IRF3/NF-κB signaling pathway, thus attenuating the inflammatory response [1].
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    • LB244
      T79730
      LB244, a homologue of BB-Cl-amidine, functions as an orally effective STING inhibitor with an EC50 value of 0.8 μM, applicable in the treatment of STING-dependent inflammatory diseases. However, pharmacokinetic studies have shown that LB244 exhibits limited oral activity in mice [1].
      • $198
      35 days
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    • STING-IN-7
      T81082899947-07-0
      STING-IN-7 (compound 21) serves as a potent inhibitor of the stimulator of interferon genes (STING) pathway, demonstrating an inhibitory concentration (IC50) of 11.5 nM. It effectively hampers the phosphorylation of both STING and interferon regulatory factor 3 (IRF3) [1].
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    • diABZI STING agonist-1
      T737462138299-33-7
      diABZI STING agonist-1 is a selective and potent interferon gene-stimulating receptor (STING) agonist with potential antitumor and anti-inflammatory activity for the study of cancer.
      • $148
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    • STING-IN-2
      T9028346691-38-1
      STING-IN-2 (C-170) is a potent and covalent inhibitor of STING. C-170 efficiently inhibits both mouse STING (mmSTING) and human STING (hsSTING). It can be used for autoinflammatory disease research.
      • $45
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    • Cridanimod
      T531738609-97-1
      Cridanimod (10-carboxymethyl-9-acridanone, CMA) is a potent STING agonist that directly binds to STING and triggers a strong antiviral response through the TBK1/IRF3 route.
      • $30
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    • STING agonist-4
      T130152138300-40-8
      STING agonist-4 is an agonist of stimulator of Interferon Genes (STING) receptor(IC50 of 20 nM).
      • $163
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    • F-CRI1
      T79199
      F-CRI1, a potent STING agonist with a dissociation constant (K d) of 40.62 nM, is an 18F-labeled radioactive probe employed for visualizing STING in the tumor microenvironment [1].
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    • Antitumor agent-114
      T793202757762-91-5
      Antitumor Agent-114, a potent STING (stimulator of interferon genes) agonist, activates immune responses and diminishes tumor size in mouse breast cancer models, demonstrating potential applications in immunity and cancer research [1].
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    • C-178
      T7329329198-87-0
      C-178 is a covalent inhibitor of STING, binds to Cys91 on STING to block its palmitoylation and prevents recruitment and phosphorylation of TBK1 in HEK293T cells.
      • $37
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    • SN-001
      T9204727699-84-5
      SN-001 was reported as a STING inhbiitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING- mediated disease.
      • $47
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    • ChX710
      T136132438721-44-7
      ChX710 activates the type I interferon response to cytosolic DNA by priming specific Interferon-Stimulated Genes (ISGs), inducing the ISRE promoter sequence, and facilitating the phosphorylation of Interferon Regulatory Factor (IRF) 3.
      • $92
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    • SAP-04
      T79779
      SAP-04 is a potent, orally active STING agonist exhibiting significant immunomodulatory effects appropriate for cancer therapy [1].
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    • STING-IN-3
      T90292244881-69-2
      STING-IN-3 (C-171) is an inhibitor of stimulator of interferon genes (STING). It binds to STING, inhibits its palmitoylation, and prevents the recruitment and phosphorylation of TBK1.
      • $45
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    • STING-IN-5
      T750112920064-17-9
      STING-IN-5, a potent inhibitor of the Stimulator of Interferon Genes (STING) pathway, significantly suppresses lipopolysaccharide (LPS)-induced nitric oxide (NO) synthesis in macrophages, exhibiting an IC50 of 1.15 μM. This compound dampens the inflammatory response and offers potential for research into anti-inflammatory diseases and sepsis [1].
      • $1,370
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    • STING activator Compound 53
      T98532259624-71-8
      STING activator Compound 53 based on an oxindole core structure demonstrated robust on-target functional activation of STING (human EC50 185 nM) in immortalised and primary cells and a cytokine induction fingerprint consistent with STING activation.
      • $34
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    • BI 7446
      T793132767011-00-5
      BI 7446 is a potent and selective cyclic dinucleotide (CDN)-based stimulator of interferon genes (STING) agonist capable of activating all five STING variants in cells, thus inducing tumor-specific immune-mediated tumor rejection. This compound is utilized in immuno-oncology research [1].
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    • SN-011
      T91372249435-90-1
      SN-011 (GUN35901) is a STING inhibitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING- mediated disease. It is a demethyl analogue of DUN99845.
      • $48
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