Shopping Cart

Remove All
Your shopping cart is currently empty

Immunology/Inflammation

Aryl Hydrocarbon Receptor

Immunology/Inflammation related

NOD-like Receptor (NLR)

Prostaglandin Receptor

Reactive Oxygen Species

Thrombopoietin Receptor

STING

Stimulator of interferon genes (STING), also known as transmembrane protein 173 (TMEM173) and MPYS/MITA/ERIS is a protein that in humans is encoded by the STING1 gene. STING plays an important role in innate immunity. STING induces type I interferon production when cells are infected with intracellular pathogens, such as viruses, mycobacteria and intracellular parasites. Type I interferon, mediated by STING, protects infected cells and nearby cells from local infection by binding to the same cell that secretes it (autocrine signaling) and nearby cells (paracrine signaling.) It thus plays an important role, for instance, in controlling norovirus infection. STING works as both a direct cytosolic DNA sensor (CDS) and an adaptor protein in Type I interferon signaling through different molecular mechanisms. It has been shown to activate downstream transcription factors STAT6 and IRF3 through TBK1, which are responsible for antiviral response and innate immune response against intracellular pathogen.

Filter HomeSignaling PathwaysImmunology/InflammationSTING

2',3'-cGAMP sodium

T10065L2734858-36-5In house

2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium) is a second messenger in cellular innate immunity, catalyzed by cGAMP synthase (cGAS) under DNA binding conditions. It binds to STING to form a dimer, inducing the production and expression of interferon-β and other cytokines.

$247

In Stock

Size

QTY

diABZI STING agonist-1 trihydrochloride

T55162138299-34-8In house

diABZI STING agonist-1 (trihydrochloride) is a stimulator of interferon genes (STING) receptor agonist.

$175

In Stock

Size

QTY

diABZI STING agonist-1 (Tautomerism)

T110352138498-18-5

diABZI STING agonist-1 (Tautomerism) (diABZI STING agonist (Compound 3)) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively.

$168

In Stock

Size

QTY

Vadimezan

T6273117570-53-3

Vadimezan (DMXAA) is a vascular disrupting agent, a murine STING agonist, and an inducer of cytokines such as type I IFN. Vadimezan has antitumor activity and induces a rapid cessation of blood flow in tumors without affecting blood flow in normal tissues.

In Stock

Size

QTY

H-151

T5674941987-60-6

H-151 is a highly potent and selective STING antagonist. H-151 covalently binds to Cys91 of STING and inhibits palmitoylation of Cys91, thereby inhibiting STING activity. H-151 can be used in the study of autoinflammatory diseases in vivo and ex vivo.

In Stock

Size

QTY

Dazostinag disodium

T724822553413-93-5In house

Dazostinag disodium (TAK-676) is a synthetic novel interferon gene (STING) agonist that triggers STING signaling pathway activation and type I interferon activation. Dazostinag disodium (TAK-676) is also a highly effective immune system modulator with complete resolution and lasting memory of T cell immunity and the ability to promote lasting interferon-dependent anti-tumor immune responses.

$498

In Stock

Size

QTY

Omaveloxolone

T69191474034-05-3

Omaveloxolone (RTA-408) (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-κB signaling. Phase 2.

In Stock

Size

QTY

Cyclic-di-GMP disodium

T369832222132-40-1

Cyclic-di-GMP disodium (5GP-5GP disodium) is a STING agonist and a second messenger in bacteria. It is involved in a variety of processes in prokaryotes, including biofilm formation, motility, and cell cycle progression. Cyclic-di-GMP disodium (5GP-5GP disodium) exhibits antiproliferative activity against cancer cells, inducing increased CD4 receptor expression and cell cycle arrest, and is a novel therapeutic agent that can be developed to prevent or treat cancer.

$139

In Stock

Size

QTY

SR-717

T86552375421-09-1

SR-717 is a cGAMP analog, a non-nucleoside STING agonist that induces a closed activation conformation of STING. SR-717 has antitumor activity and promotes activation of immune cells and cross-presentation of antigens.

In Stock

Size

QTY

MSA-2

T8798129425-81-6

MSA-2 is an orally available non-nucleotide STING agonist. The non-covalent dimer of MSA-2 binds to STING with nanomolar affinity. It shows anti-tumor activity in syngeneic mouse tumor models, synergizes with anti-PD-1, stimulates tumor secretion of interferon-β, induces tumor regression, and has long-lasting anti-tumor immunity. [3]

In Stock

Size

QTY

diABZI STING agonist-1

T737462138299-33-7In house

diABZI STING agonist-1 is a selective and potent interferon gene-stimulating receptor (STING) agonist with potential antitumor and anti-inflammatory activity for the study of cancer.

$148

In Stock

Size

QTY

C-176

T5154314054-00-7

C-176 (STING inhibitor 1) is a STING inhibitor with selectivity and blood-brain barrier permeability. C-176 inhibits STING-mediated IFNβ production and possesses anti-inflammatory activity.

In Stock

Size

QTY

CCCP

T7081555-60-2

CCCP (Carbonyl Cyanide m-Chlorophenylhydrazone) is an oxidative phosphorylation (OXPHOS) inhibitor and mitochondrial proton carrier uncoupler. CCCP inhibits the activation of STING and its downstream signaling molecules TBK1 and IRF3.

In Stock

Size

QTY

SN-011

T91372249435-90-1

SN-011 (GUN35901) is a STING inhibitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING- mediated disease. It is a demethyl analogue of DUN99845.

In Stock

Size

QTY

Gelsevirine

TN167838990-03-3

Gelsevirine, a novel STING-specific inhibitor, is an alkaloid from Gelsemium elegans with anxiolytic and antiproliferative activities that inhibits interferon and inflammatory cytokine induction in macrophages exposed to STING agonists, and attenuates STING-related inflammation in sepsis.

$243

In Stock

Size

QTY

STING activator Compound 53

T98532259624-71-8

STING activator Compound 53 based on an oxindole core structure demonstrated robust on-target functional activation of STING (human EC50 185 nM) in immortalised and primary cells and a cytokine induction fingerprint consistent with STING activation.

In Stock

Size

QTY

Cridanimod

T531738609-97-1

Cridanimod (10-carboxymethyl-9-acridanone, CMA) is a potent STING agonist that directly binds to STING and triggers a strong antiviral response through the TBK1 IRF3 route.

In Stock

Size

QTY

diABZI-C2-NH2

T395972137975-93-8

diABZI-C2-NH2 is an agonist of the interferon gene STING that modulates STING-dependent type I interferon production and can be used to study STING-mediated diseases.

$699

In Stock

Size

QTY

STING agonist-1

T8328702662-50-8

STING agonist-1 (G10) is a human-specific agent that elicits antiviral activity against emerging Alphaviruses.

In Stock

Size

QTY

STING-IN-2

T9028346691-38-1

STING-IN-2 (C-170) is a potent, covalent inhibitor of STING, effectively targeting both mouse (mmSTING) and human STING (hsSTING), and is applicable for autoinflammatory disease research.

In Stock

Size

QTY

STING agonist-4

T130152138300-40-8

STING agonist-4 is an agonist of stimulator of Interferon Genes (STING) receptor(IC50 of 20 nM).

$163

In Stock

Size

QTY

STING-IN-3

T90292244881-69-2

STING-IN-3 (C-171) is an inhibitor of stimulator of interferon genes (STING). It binds to STING, inhibits its palmitoylation, and prevents the recruitment and phosphorylation of TBK1.

In Stock

Size

QTY

SN-001

T9204727699-84-5

SN-001 was reported as a STING inhbiitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING- mediated disease.

In Stock

Size

QTY