Shopping Cart
- Remove All
Your shopping cart is currently empty
Anti-PIK3CB Antibody (8S549)
😃Good
Catalog No. TMAH-00979
Alias PtdIns-3-kinase subunit p110-beta, PtdIns-3-kinase subunit beta, PIK3C1, PI3-kinase subunit beta, PI3K-beta, PI3Kbeta, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform, Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta, p110beta, EC 2.7.1.153
Anti-PIK3CB Antibody (8S549) is an antibody targeting PIK3CB. Anti-PIK3CB Antibody (8S549) can be used in ELISA, WB, IP.
Anti-PIK3CB Antibody (8S549)
Anti-PIK3CB Antibody (8S549)
😃Good
Catalog No. TMAH-00979Alias PtdIns-3-kinase subunit p110-beta, PtdIns-3-kinase subunit beta, PIK3C1, PI3-kinase subunit beta, PI3K-beta, PI3Kbeta, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform, Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta, p110beta, EC 2.7.1.153
Anti-PIK3CB Antibody (8S549) is an antibody targeting PIK3CB. Anti-PIK3CB Antibody (8S549) can be used in ELISA, WB, IP.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $207 | 7-10 days | |
| 100 μL | $347 | 7-10 days |
Bulk & Custom
Add to Cart
Questions
View MoreContact us for more batch information
Resource Download
Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-PIK3CB Antibody (8S549) is an antibody targeting PIK3CB. Anti-PIK3CB Antibody (8S549) can be used in ELISA, WB, IP. |
| Alias | PtdIns-3-kinase subunit p110-beta, PtdIns-3-kinase subunit beta, PIK3C1, PI3-kinase subunit beta, PI3K-beta, PI3Kbeta, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform, Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta, p110beta, EC 2.7.1.153 |
| Ig Type | Rabbit IgG |
| Clone | 8S549 |
| Reactivity | Human |
| Verified Activity | 1. Western Blot -Positive WB detected in: Hela whole cell lysate, K562 whole cell lysate -All lanes: PIK3CB antibody at 1:1500 -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 123 kDa -Observed band size: 110 kDa 2. Immunoprecipitating PIK3CB in K562 whole cell lysate -Lane 1: Rabbit control IgG instead of TMAH-00979 in K562 whole cell lysate. For western blotting,a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000) -Lane 2: TMAH-00979(2µg)+ K562 whole cell lysate(500µg) -Lane 3: K562 whole cell lysate (10µg) |
| Application | ELISA, WB, IP |
| Recommended Dose | WB:1:500-1:5000; IP:1:200-1:1000. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Cytoplasm. Nucleus. Note=Interaction with PIK3R2 is required for nuclear localization and export. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol derivatives at position 3 of the inositol ring to produce 3-phosphoinositides. Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces. Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2). Has a role in cell survival. May have a role in cell migration. Involved in the early stage of autophagosome formation. Modulates the intracellular level of PtdIns3P (phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity. May act as a scaffold, independently of its lipid kinase activity to positively regulate autophagy. May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required. May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis. Mediator of oncogenic signal in cell lines lacking PTEN. The lipid kinase activity is necessary for its role in oncogenic transformation. Required for the growth of ERBB2 and RAS driven tumors. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human PI3 Kinase p110 beta |
| Antigen Species | Human |
| Gene ID | 5291 |
| Uniprot ID | |
| Biology Area | Cell biology, Immunology, Signal transduction |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
Sci Citations
Calculator
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy Anti-PIK3CB Antibody (8S549) | purchase Anti-PIK3CB Antibody (8S549) | Anti-PIK3CB Antibody (8S549) cost | order Anti-PIK3CB Antibody (8S549)
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.