Shopping Cart

Your shopping cart is currently empty

C12-200

Name: C12-200
Brand: TargetMol
SKU: T38604
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: C12-200) Copy Product Info

🥰Excellent

Hot

Synonyms: C12-200

Catalog No. T38604 Copy Product Info

Purity: 99.68%

🥰Excellent

Hot

C12-200 is a five-tail/branched ionizable cationic lipid that serves as a benchmark lipid material in RNA delivery, demonstrating exceptional performance in mRNA and siRNA lipid nanoparticle (LNP) formulations.

Cas No. 1220890-25-4

Pack Size	Price	USA Stock	Global Stock
1 mg	$32	-	In Stock
5 mg	$73	-	In Stock
10 mg	$123	In Stock	In Stock
25 mg	$198	In Stock	In Stock
50 mg	$372	-	In Stock
100 mg	$619	-	In Stock
200 mg	$877	-	In Stock
1 mL x 10 mM (in DMSO)	$153	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

Add to Cart

Add to Quotation

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

Batch Information

Select Batch

Purity:99.68%

Color:Yellow

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	C12-200 is a five-tail/branched ionizable cationic lipid that serves as a benchmark lipid material in RNA delivery, demonstrating exceptional performance in mRNA and siRNA lipid nanoparticle (LNP) formulations.
In vitro	Methods: After intraperitoneal injection of siRNA-Cy5.5 (C12-200) LNPs (1 mg/kg) in mice, peritoneal lavage fluid was collected at 6 and 24 hours to analyze Cy5.5 signal in F4/80ᵸⁱ CD11bᵸⁱ macrophages (LPMs). Results: At both 6h and 24h, the mean fluorescence intensity of Cy5.5 and the percentage of Cy5.5⁺ cells in LPMs were significantly elevated. [1]
In vivo	Methods: Acute liver injury was induced in mice by intraperitoneal injection of APAP (300 mg/kg). Six hours later, siRNA-Cy5 (C12-200) LNPs (1 mg/kg siRNA) were administered via intraperitoneal injection. Results: It was demonstrated that GLPMs enter the bloodstream following liver injury and were successfully labeled by C12-200 LNP. [2]
Synonyms	C12-200

Chemical Properties

Molecular Weight	1136.93
Formula	C₇₀H₁₄₅N₅O₅
Cas No.	1220890-25-4
Smiles	CCCCCCCCCCC(O)CN(CCN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC)CCN1CCN(CCN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC)CC1
Relative Density.	0.948 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Keep away from moisture,Store at low temperature Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (79.16 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (2.9 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.8796 mL	4.3978 mL	8.7956 mL	43.9781 mL
5 mM	0.1759 mL	0.8796 mL	1.7591 mL	8.7956 mL
10 mM	0.0880 mL	0.4398 mL	0.8796 mL	4.3978 mL
20 mM	0.0440 mL	0.2199 mL	0.4398 mL	2.1989 mL
50 mM	0.0176 mL	0.0880 mL	0.1759 mL	0.8796 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.