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Catalog No. T38562Cas No. 1175017-90-9
AKN-028 is an orally active and potent FLT3 tyrosine kinase inhibitor ( IC 50 = 6 nM). AKN-028 causes dose-dependent inhibition of FLT3 autophosphorylation.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
5 mg$53In Stock
10 mg$88In Stock
25 mg$187In Stock
50 mg$294In Stock
100 mg$429In Stock
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Product Introduction

AKN-028 is an orally active and potent FLT3 tyrosine kinase inhibitor ( IC 50 = 6 nM). AKN-028 causes dose-dependent inhibition of FLT3 autophosphorylation.
In vitro
AKN-028 triggers apoptosis in MV4-11 by activation of caspase 3 [1] . AKN-028 (10 μM) is cytotoxic to AML cell lines and induces apoptosis in the AML cell line MV4-11 [1] . Cell Cytotoxicity Assay [1] Cell Line: AML cell line MV4-11. Concentration: 10 μM. Incubation Time: 24 h. Result: Was cytotoxic to primary AML cells, irrespective of FLT3 mutation status and quantitative FLT3 expression.
In vivo
AKN-028 (15?mg/kg, Subcutaneously injection twice daily) exhibits anti-tumor activities for acute myeloid leukemia (AML) models [1] . Animal Model: Mice based AML and MV4-11 cells [1] . Dosage: 15?mg/kg. Administration: Subcutaneously injection twice daily. Result: Inhibited net growth of one of the primary AML samples (UPN26) in vivo and furthermore reduced the tumor mass of MV4-11 cell line.
Chemical Properties
Molecular Weight302.33
Cas No.1175017-90-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 20 mg/mL 66.15 mM)
Solution Preparation Table
1 mM3.3076 mL16.5382 mL33.0764 mL165.3822 mL
5 mM0.6615 mL3.3076 mL6.6153 mL33.0764 mL
10 mM0.3308 mL1.6538 mL3.3076 mL16.5382 mL
20 mM0.1654 mL0.8269 mL1.6538 mL8.2691 mL
50 mM0.0662 mL0.3308 mL0.6615 mL3.3076 mL


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