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Bempegaldesleukin
(Synonyms: NKTR-214, BEMPEG) Copy Product Info
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Synonyms: NKTR-214, BEMPEG
Catalog No. TP2549 Copy Product Info
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Bempegaldesleukin (NKTR-214) is a PEGylated interleukin-2 (IL-2) that functions as an immunostimulatory IL-2 proagent, acting as a CD122-preferential agonist of the IL-2 pathway. It can stimulate an antitumor immune response [1].
Bempegaldesleukin
Cas No. 1939126-74-5
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | Bempegaldesleukin (NKTR-214) is a PEGylated interleukin-2 (IL-2) that functions as an immunostimulatory IL-2 proagent, acting as a CD122-preferential agonist of the IL-2 pathway. It can stimulate an antitumor immune response [1]. |
| In vitro | Bempegaldesleukin is an IL-2 prodrug that has been engineered to provide controlled, sustained, and preferential signaling through the IL-2 pathway, aiming to stimulate anti-tumor immune responses while minimizing toxicity [1]. |
| In vivo | Administering Bempegaldesleukin (0.8 mg/kg; i.v. for 7 days) combined with NKTR-262 significantly enhances survival rates in CD8+ T cell-dependent manner across two tumor models (CT26 and EMT6) [2]. |
| Synonyms | NKTR-214, BEMPEG |
| Cas No. | 1939126-74-5 |
| Sequence | {X}-Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe (X= O-methylpolyethylene glycol (2 x 20 kDa mPEG)-Aib) |
| Sequence Short | SVSEIQLMHNLGKHLNSMERVEWLRKKLQDVHNF |
| Storage | -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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Related Tags: Bempegaldesleukin in vivo | Bempegaldesleukin in vitro
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