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Bempegaldesleukin

(Synonyms: NKTR-214, BEMPEG) Copy Product Info
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Synonyms: NKTR-214, BEMPEG

Catalog No. TP2549 Copy Product Info
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Bempegaldesleukin (NKTR-214) is a PEGylated interleukin-2 (IL-2) that functions as an immunostimulatory IL-2 proagent, acting as a CD122-preferential agonist of the IL-2 pathway. It can stimulate an antitumor immune response [1].
Bempegaldesleukin
Cas No. 1939126-74-5
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For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
Bempegaldesleukin (NKTR-214) is a PEGylated interleukin-2 (IL-2) that functions as an immunostimulatory IL-2 proagent, acting as a CD122-preferential agonist of the IL-2 pathway. It can stimulate an antitumor immune response [1].
In vitro
Bempegaldesleukin is an IL-2 prodrug that has been engineered to provide controlled, sustained, and preferential signaling through the IL-2 pathway, aiming to stimulate anti-tumor immune responses while minimizing toxicity [1].
In vivo
Administering Bempegaldesleukin (0.8 mg/kg; i.v. for 7 days) combined with NKTR-262 significantly enhances survival rates in CD8+ T cell-dependent manner across two tumor models (CT26 and EMT6) [2].
SynonymsNKTR-214, BEMPEG
Chemical Properties
Cas No.1939126-74-5
Sequence{X}-Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe (X= O-methylpolyethylene glycol (2 x 20 kDa mPEG)-Aib)
Sequence ShortSVSEIQLMHNLGKHLNSMERVEWLRKKLQDVHNF
Storage & Solubility Information
Storage-20°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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Related Tags: Bempegaldesleukin in vivo | Bempegaldesleukin in vitro