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Neohesperidin

Name: Neohesperidin
Brand: TargetMol
SKU: T2737
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2737Cas No. 13241-33-3

Alias NSC 31048, Hesperetin 7-O-neohesperidoside

Neohesperidin (NSC-31048) with antioxidant and neuroprotective properties. Unlike other citrus flavanones, it does not inhibit oral carcinogenesis in a rat model.

Neohesperidin

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Purity: 98.53%

Catalog No. T2737Alias NSC 31048, Hesperetin 7-O-neohesperidosideCas No. 13241-33-3

Neohesperidin (NSC-31048) with antioxidant and neuroprotective properties. Unlike other citrus flavanones, it does not inhibit oral carcinogenesis in a rat model.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$39	In Stock	In Stock
100 mg	$51	In Stock	In Stock
500 mg	$189	-	In Stock
1 g	$312	-	In Stock
5 g	$713	-	In Stock
1 mL x 10 mM (in DMSO)	$43	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.53%

Color:White

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COA HPLC HNMR LCMS

Product Introduction

Bioactivity

Description	Neohesperidin (NSC-31048) with antioxidant and neuroprotective properties. Unlike other citrus flavanones, it does not inhibit oral carcinogenesis in a rat model.
In vivo	Neohesperidin, administered at a dose of 50 mg/kg, significantly reduces the occurrence of HCl/ethanol-induced gastric lesions by 55.0%. In studies involving pylorus-ligated rats, this compound notably decreases both the volume of gastric secretion and gastric acid output, while simultaneously increasing gastric pH[1]. Additionally, neohesperidin treatment markedly improves glucose metabolism and insulin sensitivity in diabetic mice, evidenced by substantial reductions in fasting glucose, serum glucose, glycosylated serum protein (GSP), serum triglycerides, total cholesterol, and leptin levels, alongside a decrease in the liver index. It also enhances oral glucose tolerance and reduces insulin resistance in these mice[3].
Synonyms	NSC 31048, Hesperetin 7-O-neohesperidoside

Chemical Properties

Molecular Weight	610.56
Formula	C₂₈H₃₄O₁₅
Cas No.	13241-33-3
Smiles	O=C1C=2C(O[C@@H](C1)C3=CC(O)=C(OC)C=C3)=CC(O[C@H]4[C@H](O[C@H]5[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O5)[C@@H](O)[C@H](O)[C@@H](CO)O4)=CC2O
Relative Density.	1.447 g/cm3. Temperature:20 °C.;1.447 g/cm3. Temperature:20 °C.

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (163.78 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (6.55 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6378 mL	8.1892 mL	16.3784 mL	81.8920 mL
5 mM	0.3276 mL	1.6378 mL	3.2757 mL	16.3784 mL
10 mM	0.1638 mL	0.8189 mL	1.6378 mL	8.1892 mL
20 mM	0.0819 mL	0.4095 mL	0.8189 mL	4.0946 mL
50 mM	0.0328 mL	0.1638 mL	0.3276 mL	1.6378 mL
100 mM	0.0164 mL	0.0819 mL	0.1638 mL	0.8189 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc