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SSTC3

Name: SSTC3
Brand: TargetMol
SKU: T13004
Price: 149 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13004Cas No. 1242422-09-8

SSTC3 is a casein kinase 1α (CK1α) activator and a potent HIF1α inhibitor, each with a Kd of 32 nM. It has potential antitumor activity, inhibits WNT signaling, and suppresses SHH medulloblastoma tumor growth.

SSTC3

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Purity: 99.94%

Catalog No. T13004Cas No. 1242422-09-8

Pack Size	Price	Availability	Quantity
1 mg	$149	In Stock
1 mL x 10 mM (in DMSO)	$263	In Stock

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Purity:99.94%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	SSTC3 is a casein kinase 1α (CK1α) activator and a potent HIF1α inhibitor, each with a Kd of 32 nM. It has potential antitumor activity, inhibits WNT signaling, and suppresses SHH medulloblastoma tumor growth.
In vitro	In colorectal cancer (CRC) cell lines, the results of SSTC3 (0-1 μM; 5 days) indicate that SSTC3 decreased cell viability[1].
In vivo	In five-week-old Apcmin mice, SSTC3 (10 mg/kg; intraperitoneal injection, for 1 month) inhibited the growth of tumors driven by Apc mutation[1].

Chemical Properties

Molecular Weight	518.53
Formula	C₂₃H₁₇F₃N₄O₃S₂
Cas No.	1242422-09-8
Smiles	CN(c1ccc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(=O)Nc1nc(cs1)-c1ccccn1
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (192.85 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (7.71 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9285 mL	9.6426 mL	19.2853 mL	96.4264 mL
5 mM	0.3857 mL	1.9285 mL	3.8571 mL	19.2853 mL
10 mM	0.1929 mL	0.9643 mL	1.9285 mL	9.6426 mL
20 mM	0.0964 mL	0.4821 mL	0.9643 mL	4.8213 mL
50 mM	0.0386 mL	0.1929 mL	0.3857 mL	1.9285 mL
100 mM	0.0193 mL	0.0964 mL	0.1929 mL	0.9643 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc