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SSTC3

Name: SSTC3
Brand: TargetMol
SKU: T13004
Price: 100 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13004Cas No. 1242422-09-8

SSTC3 is a casein kinase 1α (CK1α) activator and a potent HIF1α inhibitor, each with a Kd of 32 nM. It has potential antitumor activity, inhibits WNT signaling, and suppresses SHH medulloblastoma tumor growth.

SSTC3

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Purity: 99.94%

Catalog No. T13004Cas No. 1242422-09-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$100	-	In Stock
5 mg	$247	-	In Stock
10 mg	$396	-	In Stock
25 mg	$648	-	In Stock
50 mg	$912	-	In Stock
100 mg	$1,220	-	In Stock
1 mL x 10 mM (in DMSO)	$250	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.94%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	SSTC3 is a casein kinase 1α (CK1α) activator and a potent HIF1α inhibitor, each with a Kd of 32 nM. It has potential antitumor activity, inhibits WNT signaling, and suppresses SHH medulloblastoma tumor growth.
In vitro	In colorectal cancer (CRC) cell lines, the results of SSTC3 (0-1 μM; 5 days) indicate that SSTC3 decreased cell viability[1].
In vivo	In five-week-old Apcmin mice, SSTC3 (10 mg/kg; intraperitoneal injection, for 1 month) inhibited the growth of tumors driven by Apc mutation[1].

Chemical Properties

Molecular Weight	518.53
Formula	C₂₃H₁₇F₃N₄O₃S₂
Cas No.	1242422-09-8
Smiles	CN(c1ccc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(=O)Nc1nc(cs1)-c1ccccn1
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (192.85 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (7.71 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9285 mL	9.6426 mL	19.2853 mL	96.4264 mL
5 mM	0.3857 mL	1.9285 mL	3.8571 mL	19.2853 mL
10 mM	0.1929 mL	0.9643 mL	1.9285 mL	9.6426 mL
20 mM	0.0964 mL	0.4821 mL	0.9643 mL	4.8213 mL
50 mM	0.0386 mL	0.1929 mL	0.3857 mL	1.9285 mL
100 mM	0.0193 mL	0.0964 mL	0.1929 mL	0.9643 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc