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Anti-Prohibitin Antibody (1C561)

😃Good
Catalog No. TMAC-03437

Anti-Prohibitin Antibody (1C561) is a Rabbit antibody targeting Prohibitin. Anti-Prohibitin Antibody (1C561) can be used in WB,ICC,IHC,IP,FCM.

Anti-Prohibitin Antibody (1C561)

Anti-Prohibitin Antibody (1C561)

😃Good
Catalog No. TMAC-03437
Anti-Prohibitin Antibody (1C561) is a Rabbit antibody targeting Prohibitin. Anti-Prohibitin Antibody (1C561) can be used in WB,ICC,IHC,IP,FCM.
Pack SizePriceAvailabilityQuantity
50 μL$2987-10 days
100 μL$4967-10 days
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Product Introduction

Bioactivity
Description
Anti-Prohibitin Antibody (1C561) is a Rabbit antibody targeting Prohibitin. Anti-Prohibitin Antibody (1C561) can be used in WB,ICC,IHC,IP,FCM.
Ig Type
IgG
Reactivity
Human,Mouse,Rat,zebrafish
Application
Recommended Dose
WB: 1:1000-2000; IHC: 1:200-500; ICC: 1:50-200; FCM: 1:50-100
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionRecombinant Antibody
PurificationProA affinity purified
AppearanceLiquid
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Research BackgroundProhibitin is an evolutionarily conserved protein that has antiproliferative activity. The gene encoding human prohibitin maps to chromosome 17q21 and is ubiquitously expressed. Prohibitin is a post-synthetically modified protein that is localized in the inner membrane of mitochondria, where it regulates the cell cycle by blocking the transition between the G1 and S phases, and on the plasma membrane of B cells, where it mediates B cell maturation. Prohibitin mRNA and protein levels are high in G1, decline during the S phase, rise again in G2 and decline in M phase, which suggests that prohibitin controls the cell cycle by using both transcriptional and posttranslational mechanisms. Prohibitin is also a potential tumor suppressor protein that binds to retinoblastoma (Rb) and subsequently inhibits the activity of E2F family members in response to specific signaling cascades. Prohibitin 2 is a repressor of estrogen receptor activity, and is required for somatic and germline differentiation in the larval gonad during embryonic development. Mutations in the Prohibitin genes are correlated with breast cancer development and/or progressionin more than 80% of the cell lines analyzed.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Protein
Antigen Species
Recombinant Protein
Uniprot ID
Chemical Properties
Molecular WeightTheoretical: 30 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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