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Citric acid

Name: Citric acid
Brand: TargetMol
SKU: T5S0636
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5S0636Cas No. 77-92-9

Alias Citro, Citretten

Citric acid (Citro) is a weak organic tricarboxylic acid found in citrus fruits. Citric acid is a food additive and a natural preservative.

Citric acid

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Purity: 98.88%

Catalog No. T5S0636Alias Citro, CitrettenCas No. 77-92-9

Citric acid (Citro) is a weak organic tricarboxylic acid found in citrus fruits. Citric acid is a food additive and a natural preservative.

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$38	In Stock	In Stock
1 g	$54	In Stock	In Stock
5 g	$129	-	In Stock
10 g	$189	-	In Stock
25 g	$319	-	In Stock
1 mL x 10 mM (in DMSO)	$44	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:98.88%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Citric acid (Citro) is a weak organic tricarboxylic acid found in citrus fruits. Citric acid is a food additive and a natural preservative.
Targets&IC50	GF:0.28 per cent, HaCaT cells:12.5 mM
In vitro	METHODS: HaCaT cells were treated with Citric acid (0-12.5 mM) for 24 hours, and the percentage of viable cells was determined by flow cytometry. RESULTS: Citric acid exhibited anti-proliferative activity in a dose-dependent manner. [1] METHODS: HaCaT cells were treated with Citric acid (12.5 mM) for 48 hours, and the levels of related proteins were detected by western blot. RESULTS: Citric acid increased the expressions of FAS, BAX, BID, AIF, EndoG, cytochrome C, PARP, GADD153, GRP78 and Caspase-3, -8, -9, and decreased the expressions of BCL-2 and BCL-Xl. [1]
In vivo	METHODS: To study the effect of Citric acid on the liver of mice, Citric acid (120, 240, and 480 mg/kg) was intraperitoneally injected into mice. RESULTS: Citric acid significantly reduced the activity of GSH-Px in the liver of mice, induced an increase in the level of MDA (malondialdehyde), and increased the activity of caspase-3 to induce apoptosis in a dose-dependent manner. [2] METHODS: To study the nephrotoxicity of Citric acid, Citric acid (120, 240, and 480 mg/kg) was intraperitoneally injected into mice every week for 3 consecutive weeks. RESULTS: Citric acid causes nephrotoxicity in mice. [3]
Synonyms	Citro, Citretten

Chemical Properties

Molecular Weight	192.12
Formula	C₆H₈O₇
Cas No.	77-92-9
Smiles	OC(=O)CC(O)(CC(O)=O)C(O)=O
Relative Density.	1.67. Temperature:20 °C.
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 100 mg/mL (520.51 mM), Sonication is recommended.

DMSO: 240 mg/mL (1249.22 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (26.03 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	5.2051 mL	26.0254 mL	52.0508 mL	260.2540 mL
5 mM	1.0410 mL	5.2051 mL	10.4102 mL	52.0508 mL
10 mM	0.5205 mL	2.6025 mL	5.2051 mL	26.0254 mL
20 mM	0.2603 mL	1.3013 mL	2.6025 mL	13.0127 mL
50 mM	0.1041 mL	0.5205 mL	1.0410 mL	5.2051 mL
100 mM	0.0521 mL	0.2603 mL	0.5205 mL	2.6025 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc