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Anti-IL-3R alpha/CD123 Antibody-PE (8N292)

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Catalog No. TMAY-00941P

Anti-IL-3R alpha/CD123 Antibody-PE (8N292) is a PE-conjugated Mouse antibody targeting IL-3R alpha/CD123. Anti-IL-3R alpha/CD123 Antibody-PE (8N292) can be used in FCM.

Anti-IL-3R alpha/CD123 Antibody-PE (8N292)

Anti-IL-3R alpha/CD123 Antibody-PE (8N292)

🥰Excellent
Catalog No. TMAY-00941P
Anti-IL-3R alpha/CD123 Antibody-PE (8N292) is a PE-conjugated Mouse antibody targeting IL-3R alpha/CD123. Anti-IL-3R alpha/CD123 Antibody-PE (8N292) can be used in FCM.
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Product Introduction

Bioactivity
Description
Anti-IL-3R alpha/CD123 Antibody-PE (8N292) is a PE-conjugated Mouse antibody targeting IL-3R alpha/CD123. Anti-IL-3R alpha/CD123 Antibody-PE (8N292) can be used in FCM.
Ig Type
Monoclonal Mouse IgG2b
Clone
8N292
Reactivity
Human
Verified Activity
Flow cytometric analysis of Human IL13RA1 expression on KG-1 cells. Cells were stained with PE-conjugated anti-Human IL13RA1. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
Application
FCM
Recommended Dose
10 μl/Test, 0.1 mg/ml
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionThis antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL3RA / CD123 (rh IL3RA / CD123; TMPY-01410; NP_002174.1; Met1-Arg305) and conjugated with PE under optimum conditions, the unreacted PE was removed.
PurificationProtein A
AppearanceLiquid
FormulationPBS solution containing 0.5% BSA and 0.03%ProClin300
Research BackgroundInterleukin-3 receptor subunit alpha, also known as IL-3 receptor subunit alpha, IL-3R-alpha, CD123, and IL3RA, is a single-pass type I membrane protein that belongs to the type I cytokine receptor family and Type 5 subfamily. The specific alpha subunit of the interleukin-3 receptor (IL-3Ralpha, CD123) is strongly expressed in various leukemic blasts and leukemic stem cells and seems to be an excellent target for the therapy of leukemias. The WSXWS motif of IL3RA appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box one motif of IL3RA is required for JAK interaction and/or activation. IL3RA represents a unique marker for primitive leukemic stem cells. Targeting of IL3RA may be a promising strategy for the preferential ablation of AML cells. Aberrant IL3RA expression is a good marker for monitoring of minimal residual disease. IL3RA is strongly expressed in various leukemic blasts and leukemic stem cells and seems to be an excellent target for the therapy of leukemias. Recent studies have shown that interleukin-3 receptor alpha (CD123) is highly expressed on leukemia stem cells of patients with acute myeloid leukemia, and is correlated with tumor load and poor prognosis. CD123 was highly expressed in the bone marrow of the patients with myelodysplastic syndrome (MDS), significantly correlated with the proportion of bone marrow blasts, and thus might be the marker of MDS malignant clone. IL3RA is also a useful new marker for distinguishing B-cell disorders with circulating villous lymphocytes as its expression is characteristic of typical hairy cell leukemia (HCL) with high sensitivity and specificity.
Related Conjugates and Formulations
Conjucates
PE
Others Formats
Unconjugated/APC/FITC
Antibody Types Available
4
Antigen Details
Immunogen
Recombinant Human IL3RA / CD123 Protein (TMPY-01410)
Antigen Species
Human
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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