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Anti-PD-L1 Antibody (8A865) (Synonyms: Programmed cell death 1 ligand 1, CD274, B7 homolog 1)
Catalog No. TMAC-03141 Copy Product Info
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Anti-PD-L1 Antibody (8A865) is a Rabbit antibody targeting PD-L1. Anti-PD-L1 Antibody (8A865) can be used in IHC,WB.
Anti-PD-L1 Antibody (8A865)
Copy Product Info🥰Excellent
Catalog No. TMAC-03141
Synonyms Programmed cell death 1 ligand 1, CD274, B7 homolog 1
Anti-PD-L1 Antibody (8A865) is a Rabbit antibody targeting PD-L1. Anti-PD-L1 Antibody (8A865) can be used in IHC,WB.
Anti-PD-L1 Antibody
(8A865)
(8A865)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $296 | 7-10 days | 7-10 days | |
| 100 μL | $498 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
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| Description | Anti-PD-L1 Antibody (8A865) is a Rabbit antibody targeting PD-L1. Anti-PD-L1 Antibody (8A865) can be used in IHC,WB. |
| Synonyms | Programmed cell death 1 ligand 1, CD274, B7 homolog 1 |
| Ig Type | IgG |
| Clone | 8A865 |
| Reactivity | Human,Mouse,Rat |
| Verified Activity | 1. Western blot analysis of PD-L1 on mouse heart lysates using anti-PD-L1 antibody at 1/1,000 dilution. 2. Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-PD-L1 antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded mouse lung tissue using anti-PD-L1 antibody. Counter stained with hematoxylin.    |
| Application | |
| Recommended Dose | WB: 1:1000; IHC: 1:50-200 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | Engagement of CD28 by B7-1 (CD80) or B7-2 (CD86) in the presence of antigen promotes T cell proliferation, cytokine production, differentiation of effector T cells, and the induction of Bcl-x, a promoter of T cell survival. Conversely, engagement of CTLA4 by B7-1 or B7-2 may inhibit proliferation and IL-2 production. Pdcd-1L1 (programmed cell death ligand-1), also known as B7-H1 or PD-L1, is 290 amino acid type I transmembrane protein which is 20% and 15% identical to B7-1 and B7-2, respectively. Pdcd-1L2 has immunoglobulin V-like and C-like domains and a 30 amino acid cytoplasmic tail. It does not bind CD28, cytotoxic T-lymphocyte A4 or ICOS (inducible co-stimulator). IL-2, although produced in small amounts, is required for the effect of Pdcd-1L1 co-stimulation. The gene which encodes Pdcd-1L1 maps to human chromosome 9p24. Pdcd-1L2 (programmed cell death ligand-2) is a 73 amino acid protein which contains a signal sequence, IgV- and IgC-like domains, a transmembrane region and a cytoplasmic region. The gene which encodes Pdcd-1L2 maps to human chromosome 9p24.2. The constitutive expression of Pdcd-1L1 and Pdcd-1L2 on paren-chymal cells of heart, lung and kidney suggests that the Pdcd-1-Pdcd-L system could provide unique negative signaling to help prevent autoimmune disease. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein |
| Uniprot ID |
| Molecular Weight | Theoretical: 33 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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