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R59949

Name: R59949
Brand: TargetMol
SKU: T26019
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T26019Cas No. 120166-69-0

Alias R-59949, R 59949

R59949 is used as a Diacylglycerol kinase (DGK) inhibitor.

R59949

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Purity: 97.04%

Catalog No. T26019Alias R-59949, R 59949Cas No. 120166-69-0

R59949 is used as a Diacylglycerol kinase (DGK) inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$35	In Stock	In Stock
2 mg	$51	In Stock	In Stock
5 mg	$84	In Stock	In Stock
10 mg	$148	In Stock	In Stock
25 mg	$313	In Stock	In Stock
50 mg	$473	In Stock	In Stock
100 mg	$695	In Stock	In Stock
200 mg	$982	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$92	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.04%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

R59949 AI Summary

R59949 exhibits a range of bioactivities and potential therapeutic implications. It demonstrates inhibitory effects on diacylglycerol kinase (DGK) in both isolated platelet membranes and intact platelets, with IC50 values of 300.0 nM and 120.0 nM, respectively. Additionally, R59949 shows thermal stabilization effects on various proteins, including AMPKA2, CAMK family members, CDKs, GSK3B, JAK1, MEK2, p38beta, ERKs, PLKs, PDK1, PIM kinases, RIOK2, RSKs, SLK, and LOK. The compound exhibits antiplasmodial activity against Plasmodium falciparum with IC50 values between 7943.28 nM and 10000.0 nM after 72 hours of exposure in the SYBR green assay. Furthermore, R59949 acts as an inhibitor of several biological targets, including Tau fibril formation (IC50 of 7943.3 nM), Cruzain (IC50 of 39810.7 nM), TIM23-1 (IC50 of 12700.0 nM), BAZ2B (IC50 of 5440.0 nM), and histone lysine methyltransferase G9a (IC50 of 44668.4 nM). It also influences the hypoxia response element signaling pathway as both an agonist (IC50 of 5011.9 nM) and an antagonist (IC50 of 5011.9 nM). It induces cytotoxicity in cell viability assays with EC50 values of 3940.0 nM and 4210.0 nM and demonstrates genotoxicity (IC50 of 23109.3 nM) and DNA re-replication induction with IC50 values of 18356.4 nM and 8199.5 nM. Overall, R59949 shows significant activity across various biological processes, suggesting its potential for development in therapeutic applications targeting these pathways..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	R59949 is used as a Diacylglycerol kinase (DGK) inhibitor.
Synonyms	R-59949, R 59949

Chemical Properties

Molecular Weight	489.58
Formula	C₂₈H₂₅F₂N₃OS
Cas No.	120166-69-0
Smiles	Fc1ccc(cc1)C(=C1CCN(CCn2c(=S)[nH]c3ccccc3c2=O)CC1)c1ccc(F)cc1
Relative Density.	1.36g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (510.64 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (5.11 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0426 mL	10.2128 mL	20.4257 mL	102.1284 mL
5 mM	0.4085 mL	2.0426 mL	4.0851 mL	20.4257 mL
10 mM	0.2043 mL	1.0213 mL	2.0426 mL	10.2128 mL
20 mM	0.1021 mL	0.5106 mL	1.0213 mL	5.1064 mL
50 mM	0.0409 mL	0.2043 mL	0.4085 mL	2.0426 mL
100 mM	0.0204 mL	0.1021 mL	0.2043 mL	1.0213 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc