Shopping Cart

Your shopping cart is currently empty

FLT3-IN-4

Name: FLT3-IN-4
Brand: TargetMol
SKU: T11299
Price: 94 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T11299Cas No. 2304799-09-3

Alias FLT3 inhibitor 9u

FLT3-IN-4 (FLT3 inhibitor 9u) is a potent and orally effective Fms-like tyrosine receptor kinase 3 (FLT3; IC50=7 nM) inhibitor ,for treating acute myelogenous leukemia.

FLT3-IN-4

Copy Product Info

😃Good

Purity: 99.9%

Catalog No. T11299Alias FLT3 inhibitor 9uCas No. 2304799-09-3

FLT3-IN-4 (FLT3 inhibitor 9u) is a potent and orally effective Fms-like tyrosine receptor kinase 3 (FLT3; IC50=7 nM) inhibitor ,for treating acute myelogenous leukemia.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$94	-	In Stock
5 mg	$238	-	In Stock
10 mg	$353	-	In Stock
25 mg	$567	-	In Stock
50 mg	$768	-	In Stock
100 mg	$987	-	In Stock
500 mg	$1,980	-	In Stock
1 mL x 10 mM (in DMSO)	$262	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.9%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	FLT3-IN-4 (FLT3 inhibitor 9u) is a potent and orally effective Fms-like tyrosine receptor kinase 3 (FLT3; IC50=7 nM) inhibitor ,for treating acute myelogenous leukemia.
In vitro	FLT3-IN-4 shows potent inhibitory activities against Molm-13 and MV4-11 cells with IC50 values 0.022±0.003nM and 0.089±0.001 nM , respectively[1].
Synonyms	FLT3 inhibitor 9u

Chemical Properties

Molecular Weight	431.49
Formula	C₂₃H₂₅N₇O₂
Cas No.	2304799-09-3
Smiles	CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn(CC=C)c3ncnc(N)c23)no1
Relative Density.	1.32 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 22.5 mg/mL (52.14 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3176 mL	11.5878 mL	23.1755 mL	115.8775 mL
5 mM	0.4635 mL	2.3176 mL	4.6351 mL	23.1755 mL
10 mM	0.2318 mL	1.1588 mL	2.3176 mL	11.5878 mL
20 mM	0.1159 mL	0.5794 mL	1.1588 mL	5.7939 mL
50 mM	0.0464 mL	0.2318 mL	0.4635 mL	2.3176 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc