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P-gp inhibitor 21
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Catalog No. TP3512
P-gp inhibitor 21 (Compound 56) is a P-glycoprotein (P-gp) transport inhibitor that can reverse P-gp-mediated multidrug resistance (MDR) and demonstrates antitumor efficacy in mouse models, without significant cytotoxicity.
P-gp inhibitor 21
P-gp inhibitor 21
😃Good
Catalog No. TP3512
P-gp inhibitor 21 (Compound 56) is a P-glycoprotein (P-gp) transport inhibitor that can reverse P-gp-mediated multidrug resistance (MDR) and demonstrates antitumor efficacy in mouse models, without significant cytotoxicity.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | P-gp inhibitor 21 (Compound 56) is a P-glycoprotein (P-gp) transport inhibitor that can reverse P-gp-mediated multidrug resistance (MDR) and demonstrates antitumor efficacy in mouse models, without significant cytotoxicity. |
| In vitro | P-gp inhibitor 21 effectively reduces the proliferation of KBV200 and NCI/ADR-RES cells when used in conjunction with VNR, with IC50 values of 2.4 nM and 27.9 nM, respectively. |
| In vivo | The compound P-gp inhibitor 21, administered at 75 mg/kg via intraperitoneal injection, effectively reduces tumor growth in KBV200 xenografts in BALB/c nude mice, while restoring sensitivity of multidrug-resistant (MDR) tumors to VNR, and shows no significant toxicity. |
| Formula | C27H42N2O4 |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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